Impact of Fish Oil Supplementation and Interruption of Fructose Ingestion on Glucose and Lipid Homeostasis of Rats Drinking Different Concentrations of Fructose

Figure 6

Interruption of fructose ingestion resulted in normalization of water and food intake behavior. The average water intake (a, g), food intake (b, h), b.m. (c, i), energy intake (d, j), blood glucose (e, k), and plasma triacylglycerol (f, l) in rats drinking water enriched with 10% fructose (w/v) (a–f) and 30% fructose (w/v) (g–l). Fructose ingestion lasted 9 consecutive weeks, and it was considered day 0 for this set of data. Then, fructose was discontinued in the water, and half of the rats from the F group remained for additional 60 days (the other half was euthanized at the end of the fructose intake protocol). Results are expressed as mean ± SEM for (a–e) and (g–k) and median ± interquartile range for (f, l). Letter A indicates significant difference compared to day 0 using ANOVA with Tukey’s post hoc test for (a–e) and (g–k) and Kruskal-Wallis with Dunn’s post hoc test for (f, l) (, at baseline “day 0” and at days 30 and 60). b.m.: body mass.