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BioMed Research International
Volume 2017 (2017), Article ID 4389525, 9 pages
https://doi.org/10.1155/2017/4389525
Review Article

Nanoparticulate Tubular Immunostimulating Complexes: Novel Formulation of Effective Adjuvants and Antigen Delivery Systems

Department of Biochemistry, Microbiology and Biotechnology, Far Eastern Federal University, Sukhanova St. 8, Vladivostok 690091, Russia

Correspondence should be addressed to Nina Sanina; ur.ufvd@mn.aninas

Received 30 January 2017; Revised 11 April 2017; Accepted 11 May 2017; Published 20 July 2017

Academic Editor: Mallikarjuna Korivi

Copyright © 2017 Nina Sanina et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. M. Sanina and A. M. Popov, “Prospects for the use of glycolipids and saponins for optimization of immunostimulatory complexes (ISCOM),” in Proceedings of the 8th Congress International Phytopharm on Actual Problems of Creation of New Medicinal Preparations of Natural Origin, pp. 698–705, Mikkeli , Finland, 2004.
  2. M. T. Sanders, L. E. Brown, G. Deliyannis, and M. J. Pearse, “ISCOM™-based vaccines: the second decade,” Immunology and Cell Biology, vol. 83, no. 2, pp. 119–128, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. H.-X. Sun, Y. Xie, and Y.-P. Ye, “ISCOMs and ISCOMATRIX™,” Vaccine, vol. 27, no. 33, pp. 4388–4401, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Lövgren Bengtsson, B. Morein, and A. D. Osterhaus, “ISCOM technology-based Matrix M™ adjuvant: success in future vaccines relies on formulation,” Expert Review of Vaccines, vol. 10, no. 4, pp. 401–403, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. E. Y. Kostetsky, N. M. Sanina, A. N. Mazeika, A. V. Tsybulsky, N. S. Vorobyeva, and V. L. Shnyrov, “Tubular immunostimulating complex based on cucumarioside A2-2 and monogalactosyldiacylglycerol from marine macrophytes,” Journal of Nanobiotechnology, vol. 9, article no. 35, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. B. Morein, B. Sundquist, S. Höglund, K. Dalsgaard, and A. Osterhaus, “Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses,” Nature, vol. 308, no. 5958, pp. 457–460, 1984. View at Publisher · View at Google Scholar · View at Scopus
  7. M. J. Pearse and D. Drane, “ISCOMATRIX® adjuvant for antigen delivery,” Advanced Drug Delivery Reviews, vol. 57, no. 3, pp. 465–474, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. G. F. A. Kersten and D. J. A. Crommelin, “Liposomes and ISCOMS as vaccine formulations,” BBA - Reviews on Biomembranes, vol. 1241, no. 2, pp. 117–138, 1995. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Wikman, M. Friedman, S. Pinitkiatisakul et al., “Achieving directed immunostimulating complexes incorporation,” Expert Review of Vaccines, vol. 5, no. 3, pp. 395–403, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. I. G. Barr, A. Sjölander, and J. C. Cox, “ISCOMs and other saponin based adjuvants,” Advanced Drug Delivery Reviews, vol. 32, no. 3, pp. 247–271, 1998. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Pedebos, L. Pol-Fachin, R. Pons, C. V. Teixeira, and H. Verli, “Atomic model and micelle dynamics of QS-21 saponin,” Molecules, vol. 19, no. 3, pp. 3744–3760, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. A. M. Popov, I. A. Lee, E. Y. Kostetsky et al., “Carrier of antigen,” Patent of Russian Federation no. 2322259, Priority, June 2006.
  13. N. M. Sanina, S. N. Goncharova, and E. Y. Kostetsky, “Fatty acid composition of individual polar lipid classes from marine macrophytes,” Phytochemistry, vol. 65, no. 6, pp. 721–730, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Matsufuji, Y. Nagamatsu, and A. Yoshimoto, “Protective effects of bacterial glyceroglycolipid M874B against cell death caused by exposure to heat and hydrogen peroxide,” Journal of Bioscience and Bioengineering, vol. 89, no. 4, pp. 345–349, 2000. View at Publisher · View at Google Scholar · View at Scopus
  15. K. R. Gustafson, J. H. Cardellina, R. W. Fuller et al., “AIDS-antiviral sulfolipids from cyanobacteria (Blue-Green Algae),” Journal of the National Cancer Institute, vol. 81, no. 16, pp. 1254–1258, 1989. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Ohta, Y. Mizushina, N. Hirata et al., “Sulfoquinovosyldiacylglycerol, KM043, a new potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase type 1 from a marine red alga, gigartina tenella,” Chemical and Pharmaceutical Bulletin, vol. 46, no. 4, pp. 684–686, 1998. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Morimoto, A. Nagatsu, N. Murakami et al., “Anti-tumour-promoting glyceroglycolipids from the green alga, chlorella vulgaris,” Phytochemistry, vol. 40, no. 5, pp. 1433–1437, 1995. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Eitsuka, K. Nakagawa, M. Igarashi, and T. Miyazawa, “Telomerase inhibition by sulfoquinovosyldiacylglycerol from edible purple laver (Porphyra yezoensis),” Cancer Letters, vol. 212, no. 1, pp. 15–20, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Wu, L. Long, Y. Song et al., “A new unsaturated glycoglycerolipid from a cultured marine dinoflagellate Amphidinium carterae,” Chemical and Pharmaceutical Bulletin, vol. 53, no. 3, pp. 330–332, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. I. A. Lee, A. M. Popov, N. M. Sanina et al., “Morphological and immunological characterization of immunostimulatory complexes based on glycoglycerolipids from Laminaria japonica,” Acta Biochimica Polonica, vol. 51, no. 1, pp. 263–272, 2004. View at Google Scholar · View at Scopus
  21. S. L. Tilley, T. M. Coffman, and B. H. Koller, “Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes,” Journal of Clinical Investigation, vol. 108, no. 1, pp. 15–23, 2001. View at Publisher · View at Google Scholar · View at Scopus
  22. P. C. Calder, “Polyunsaturated fatty acids and inflammatory processes: new twists in an old tale,” Biochimie, vol. 91, no. 6, pp. 791–795, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. P. C. Calder, “Marine omega-3 fatty acids and inflammatory processes: effects, mechanisms and clinical relevance,” Biochimica et Biophysica Acta—Molecular and Cell Biology of Lipids, vol. 1851, no. 4, pp. 469–484, 2015. View at Publisher · View at Google Scholar
  24. S. R. Shaikh and M. Edidin, “Polyunsaturated fatty acids, membrane organization, T cells, and antigen presentation,” American Journal of Clinical Nutrition, vol. 84, no. 6, pp. 1277–1289, 2006. View at Google Scholar · View at Scopus
  25. P. Zhang, R. Smith, R. S. Chapkin, and D. N. McMurray, “Dietary (n-3) polyunsaturated fatty acids modulate murine Th1/Th2 balance toward the Th2 pole by suppression of Th1 development,” The Journal of Nutrition, vol. 135, no. 7, pp. 1745–1751, 2005. View at Google Scholar · View at Scopus
  26. N. M. Sanina, S. N. Goncharova, and E. Y. Kostetsky, “Seasonal changes of fatty acid composition and thermotropic behavior of polar lipids from marine macrophytes,” Phytochemistry, vol. 69, no. 7, pp. 1517–1527, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Wikström, J. Xie, M. Bogdanov et al., “Monoglucosyldiacylglycerol, a foreign lipid, can substitute for phosphatidylethanolamine in essential membrane-associated functions in Escherichia coli,” Journal of Biological Chemistry, vol. 279, no. 11, pp. 10484–10493, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. V. I. Kalinin, D. L. Aminin, S. A. Avilov, A. S. Silchenko, and V. A. Stonik, “Triterpene glycosides from sea cucucmbers (holothurioidea, echinodermata). Biological activities and functions,” Studies in Natural Products Chemistry, vol. 35, no. C, pp. 135–196, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. E. S. Menchinskaya, E. A. Pislyagin, S. N. Kovalchyk et al., “Antitumor activity of cucumarioside A2-2,” Chemotherapy, vol. 59, no. 3, pp. 181–191, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. D. L. Aminin, T. S. Zaporozhets, P. V. Adryjashchenko, S. A. Avilov, V. I. Kalinin, and V. A. Stonik, “Radioprotective properties of cumaside, a complex of triterpene glycosides from the sea cucumber Cucumaria japonica and cholesterol,” Natural Product Communications, vol. 6, no. 5, pp. 587–592, 2011. View at Google Scholar · View at Scopus
  31. J.-P. Vincken, L. Heng, A. de Groot, and H. Gruppen, “Saponins, classification and occurrence in the plant kingdom,” Phytochemistry, vol. 68, no. 3, pp. 275–297, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. V. I. Kalinin, A. S. Silchenko, and S. A. Avilov, “Taxonomic significance and ecological role of triterpene glycosides from holothurians,” Biology Bulletin, vol. 43, no. 6, pp. 532–540, 2016. View at Publisher · View at Google Scholar
  33. J. Colorado, D. Muñoz, D. Marquez et al., “Ulososides and urabosides—triterpenoid saponins from the caribbean marine sponge ectyoplasia ferox,” Molecules, vol. 18, no. 3, pp. 2598–2610, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. A. S. Silchenko, New triterpene glycosides from 8 specias of holothurians from families Holothuriidae, Stichopodidae, Synallactidae and Cucumariidae [Ph.D. thesis], Vladivostok, Russia, 2005.
  35. X. Li, A. B. Roginsky, X.-Z. Ding et al., “Review of the apoptosis pathways in pancreatic cancer and the anti-apoptotic effects of the novel sea cucumber compound, frondoside A,” Annals of the New York Academy of Sciences, vol. 1138, no. 1, pp. 181–198, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. G. N. Likhatskaya, Triterpene and sterioidal glycosides and membranes. Molecular mechanisms of interactions with membranes, LAP Lambert Academic Publishing, Berlin, Germany, 2011.
  37. A. M. Popov, Biological activity and mechanism of action of secondary metabolites from terrestrial plants and marine invertebrates [Dr. Sci. Thesis], Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia, 2003.
  38. S. A. Avilov, Triterpene glycosides from holothurians of an order Dendrochirotida [Dr. Sci. Thesis], Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok, Russia, 2000.
  39. D. L. Aminin, B. V. Pinegin, L. V. Pichugina et al., “Immunomodulatory properties of Cumaside,” International Immunopharmacology, vol. 6, no. 7, pp. 1070–1082, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. L. A. Lee, A. M. Popov, E. Ya. Kostetsky, N. M. Sanina, A. N. Mazeyka, and V. M. Boguslavskii, “Membranotropic effect of some triterpene glycosides possessing immunostimulating properties,” Biophysics, vol. 53, no. 3, pp. 462–469, 2008. View at Google Scholar
  41. V. I. Kalinin, A. S. Silchenko, S. A. Avilov, V. A. Stonik, and A. V. Smirnov, “Sea cucumbers triterpene glycosides, the recent progress in structural elucidation and chemotaxonomy,” Phytochemistry Reviews, vol. 4, no. 2, pp. 221–236, 2005. View at Google Scholar
  42. D. L. Aminin, C. Koy, P. S. Dmitrenok et al., “Immunomodulatory effects of holothurian triterpene glycosides on mammalian splenocytes determined by mass spectrometric proteome analysis,” Journal of Proteomics, vol. 72, no. 5, pp. 886–906, 2009. View at Publisher · View at Google Scholar · View at Scopus
  43. D. L. Aminin, E. S. Menchinskaya, E. A. Pisliagin, A. S. Silchenko, S. A. Avilov, and V. I. Kalinin, “Anticancer activity of sea cucumber triterpene glycosides,” Marine Drugs, vol. 13, no. 3, pp. 1202–1223, 2015. View at Publisher · View at Google Scholar · View at Scopus
  44. A. N. Mazeyka, A. M. Popov, V. I. Kalinin, S. A. Avilov, A. S. Silchenko, and E. Y. Kostetsky, “Complexation between triterpene glycosides of holothurians and cholesterol is the basis of lipid-saponin carriers of subunit protein antigens,” Biophysics, vol. 53, no. 5, pp. 826–835, 2008. View at Google Scholar
  45. E. A. J. Keukens, T. de Vrije, C. van den Boom et al., “Molecular basis of glycoalkaloid induced membrane disruption,” Biochimica et Biophysica Acta—Biomembranes, vol. 1240, no. 2, pp. 216–228, 1995. View at Publisher · View at Google Scholar · View at Scopus
  46. A. N. Mazeyka, E. Y. Kostetsky, N. M. Sanina, A. M. Popov, V. I. Kalinin, and I. A. Li, “Elaboration of immune stimulating lipid-saponin subunit antigen carrier based on glycolipid monogalactosyldiacylglycerol from sea macrophytes and triterpene glycosides from Cucumaria japonica,” Biophysics (Russian Federation), vol. 58, no. 5, pp. 616–623, 2013. View at Publisher · View at Google Scholar · View at Scopus
  47. M. J. Copland, T. Rades, and N. M. Davies, “Hydration of lipid films with an aqueous solution of Quil A: a simple method for the preparation of immune-stimulating complexes,” International Journal of Pharmaceutics, vol. 196, no. 2, pp. 135–139, 2000. View at Publisher · View at Google Scholar · View at Scopus
  48. E. Y. Kostetsky, A. M. Popov, N. M. Sanina, I. A. Lee, A. V. Tsybulsky, and V. L. Shnyrov, “Carrier and adjuvant for antigens,” Patent of Russian Federation no. 2311926, Priority, February 2006.
  49. N. M. Sanina, A. M. Popov, I. A. Lee, E. Y. Kostetsky, A. V. Tsybulsky, and V. L. Shnyrov, “Mode of forming of antigen carrier based on lipids from marine macrophytes and triterpene glycoside cucumarioside,” Patent of Russian Federation no. 2319506, Priority, October 2005.
  50. N. S. Vorobyeva, A. N. Mazeika, L. A. Davydova et al., “The effects of triterpene glycosides and phospholipids from marine invertebrates in the composition of tubular immunostimulating complexes on the immunogenicity of human serum albumin,” Russian Journal of Marine Biology, vol. 41, no. 1, pp. 69–77, 2015. View at Publisher · View at Google Scholar · View at Scopus
  51. N. M. Sanina, N. S. Vorobieva, O. D. Novikova et al., “Lipid-induced changes in protein conformation as a means to regulate the immunogenicity of antigens incorporated in tubular immunostimulating complexes,” Biophysics (Russian Federation), vol. 61, no. 3, pp. 380–386, 2016. View at Publisher · View at Google Scholar · View at Scopus
  52. N. M. Sanina, E. Y. Kostetsky, V. L. Shnyrov et al., “The influence of monogalactosyldiacylglycerols from different marine macrophytes on immunogenicity and conformation of protein antigen of tubular immunostimulating complex,” Biochimie, vol. 94, no. 4, pp. 1048–1056, 2012. View at Publisher · View at Google Scholar · View at Scopus
  53. P. Yaqoob, “Fatty acids as gatekeepers of immune cell regulation,” Trends in Immunology, vol. 24, no. 12, pp. 639–645, 2003. View at Publisher · View at Google Scholar · View at Scopus