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BioMed Research International
Volume 2017, Article ID 4519796, 5 pages
https://doi.org/10.1155/2017/4519796
Research Article

Follow-Up (Measurement) of Corrected QT Interval in Adult Patients before and after Lung Transplantation

1University of Giessen and Marburg Lung Center (UGMLC), The German Center for Lung Research (DZL), Klinikstrasse 33, 35392 Giessen, Germany
2Klinikum Westmünsterland, St. Agnes-Hospital Bocholt Rhede, Medical Clinic 1-Cardiology/Electrophysiology, Barloer Weg 125, 46397 Bocholt, Germany
3Department of General and Thoracic Surgery, University Hospital of Giessen, Rudolf-Buchheim-Strasse 7, 35392 Giessen, Germany
4Klinikum Lüdenscheid, Universität Witten-Herdecke, Medizinische Klinik III, Paulmannhöherstr. 14, 58515 Lüdenscheid, Germany
5Department of Thoracic Surgery, Kerckhoff Heart and Lung Center, Benekestrasse 2-8, 61231 Bad Nauheim, Germany
6Department of Intensive Care Medicine, Kerckhoff Heart and Lung Center, Benekestrasse 2-8, 61231 Bad Nauheim, Germany
7Medical Clinic 1, University Hospital Giessen and Marburg GmbH, Klinikstrasse 33, 35392 Giessen, Germany

Correspondence should be addressed to Dirk Bandorski; ed.nesseig-inu.dem.wkh@iksrodnab.krid

Received 5 May 2017; Revised 3 October 2017; Accepted 17 October 2017; Published 6 November 2017

Academic Editor: Paul M. Tulkens

Copyright © 2017 Dirk Bandorski et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Prolongation of the corrected QT (QTc) interval is well known for many drugs, some of which are an integral part of the therapeutic regimen after lung transplantation (LTX). Therefore, we investigated the QTc interval after LTX in the present study. Patients and Methods. The medical records of patients after LTX were studied for demographic data, indication of LTX, medication, and baseline and follow-up ECGs. The QT interval was corrected for the patient’s heart rate using the different formulae of Bazett, Fridericia, Hodges, and Framingham. Results. Fifty-nine patients were included. The mean age ± SD was years (median 58 years). After LTX, QTc intervals showed no (relevant) changes during follow-up, even though all patients were treated with drugs (in combination) known to bear a risk of prolonged QTc interval and cortisone. The longest QTc intervals were obtained using Bazett’s formula. Conclusion. The QTc interval did not increase under immunosuppressive medication after LTX in our cohort of patients. We speculate that the concurrent use of cortisone may shorten the QT(c) intervals or cancel out drug-induced prolongation of the QTc interval.