TY - JOUR
A2 - Thabet, Abdelaziz Mousa
AU - Dai, Wenjie
AU - Kaminga, Atipatsa C.
AU - Wu, Xin
AU - Wen, Shi Wu
AU - Tan, Hongzhuan
AU - Yan, Junxia
AU - Deng, Jing
AU - Lai, Zhiwei
AU - Liu, Aizhong
PY - 2017
DA - 2017/05/14
TI - Brain-Derived Neurotropic Factor Val66Met Polymorphism and Posttraumatic Stress Disorder among Survivors of the 1998 Dongting Lake Flood in China
SP - 4569698
VL - 2017
AB - Objective. This study mainly aimed to explore the association between brain-derived neurotropic factor (BDNF) Val66Met polymorphism and posttraumatic stress disorder (PTSD) among flood survivors in China. Methods. Individuals who experienced the 1998 Dongting Lake flood in Southeast Huarong, China, were enrolled in this study. Qualified health personnel carried out face-to-face interviews with participants. PTSD was identified using PTSD Checklist-Civilian version (PCL-C). Blood samples were collected from the participants to extract DNA for genotyping. Results. A total of 175 participants were enrolled in this study. The prevalence of PTSD among flood survivors at 17-year follow-up was 16.0% (28/175). Individuals with PTSD were more likely to be female, experience at least three flood-related stressors, experience at least three postflood stressors, and carry the Met than those without PTSD. Compared with Val/Val homozygotes, Met carriers had higher scores of PCL-C (mean ± standard error: 23.60±7.23 versus 27.19±9.48, P<0.05). Multivariable logistic regression analysis indicated that Met carriers (aOR = 4.76, 95% CI = 1.02–22.15, P<0.05) were more likely to develop PTSD than Val/Val homozygotes. Conclusions. Met carriers for BDNF rs6265 are at higher risk of developing PTSD and also exhibit more severe PTSD symptoms than Val/Val homozygotes among flood survivors in China.
SN - 2314-6133
UR - https://doi.org/10.1155/2017/4569698
DO - 10.1155/2017/4569698
JF - BioMed Research International
PB - Hindawi
KW -
ER -