A Simple Model for Inducing Optimal Increase of SDF-1 with Aminoglycoside Ototoxicity

Figure 6

The distribution of SDF-1 in the cochlea after treatment with furosemide 130 mg/kg + kanamycin 550 mg/kg was assessed by immunohistochemistry. SDF-1 was detected in the stria vascularis, Reissner’s membrane, organ of Corti, and spinal ganglion. (a) ×200 magnified image of the cochlea of normal control mice. (b) ×200 magnified image of the cochlea of the treated mice with furosemide 130 mg/kg + kanamycin 550 mg/kg. Furthermore, the organ of Corti showed the highest increase (d) in expression, compared to the control (c). Both outer and inner hair cells showed increased levels of SDF-1. Scale bars: 50 μm.

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