Liver X Receptor Agonist TO901317 Attenuates Paraquat-Induced Acute Lung Injury through Inhibition of NF-κB and JNK/p38 MAPK Signal Pathways

Figure 5

Effect of T0901317 on NF-κB activation and IκB-α degradation in lung tissues of mice. Lung tissues were collected to determine the nuclear expression of NF-κB p65 by Western blot (a, b) and immunohistochemistry (e, f ×400) 72 h after PQ administration. We also detected the expression of IκB-α by Western blot (c, d) after PQ administration for 72 h. TO901317L: TO901317 at the dose of 5 mg/kg; TO901317H: TO901317 at the dose of 20 mg/kg. The values presented are the mean ± SD (). versus PQ group. versus PQ + TO901317L group.