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BioMed Research International
Volume 2017 (2017), Article ID 4732520, 4 pages
https://doi.org/10.1155/2017/4732520
Research Article

A Novel Genetic Group of Bovine Hepacivirus in Archival Serum Samples from Brazilian Cattle

1Laboratório de Virologia, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil
2Institute of Veterinary Virology, University of Bern, Bern, Switzerland

Correspondence should be addressed to Cláudio W. Canal; rb.sgrfu@lanac.oidualc

Received 26 April 2017; Revised 3 July 2017; Accepted 20 July 2017; Published 20 August 2017

Academic Editor: Christen Rune Stensvold

Copyright © 2017 Cláudio W. Canal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hepatitis C virus (HCV) (genus Hepacivirus; family Flaviviridae) is a major human pathogen causing persistent infection and hepatic injury. Recently, emerging HCV-like viruses were described infecting wild animals, such as bats and rodents, and domestic animals, including dogs, horses, and cattle. Using degenerate primers for detecting bovine pestiviruses in a 1996 survey three bovine serum samples showed a low identity with the genus Pestivirus of the Flaviviridae family. A virus could not be isolated in cell culture. The description of bovine hepaciviruses (BovHepV) in 2015 allowed us to retrospectively identify the sequences as BovHepV, with a 88.9% nucleotide identity. In a reconstructed phylogenetic tree, the Brazilian BovHepV samples grouped within the bovine HCV-like cluster in a separated terminal node that was more closely related to the putative bovine Hepacivirus common ancestor than to bovine hepaciviruses detected in Europe and Africa.