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BioMed Research International
Volume 2017 (2017), Article ID 4757025, 6 pages
Research Article

Diffusion Kurtosis Imaging Detects Microstructural Changes in the Brain after Acute Alcohol Intoxication in Rats

Department of Radiology, The Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, China

Correspondence should be addressed to Wen-bin Zheng

Received 5 September 2016; Revised 26 November 2016; Accepted 12 December 2016; Published 18 January 2017

Academic Editor: Jiun-Jie Wang

Copyright © 2017 Xi-ran Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was to test the technical feasibility of diffusion kurtosis imaging (DKI) in the brain after acute alcohol intoxication. Diffusion tensor imaging (DTI) and DKI during 7.0 T MRI were performed in the frontal lobe and thalamus before and 30 min, 2 h, and 6 h after ethyl alcohol administration. Compared with controls, mean kurtosis values of the frontal lobe and thalamus first decreased by 44% and 38% within 30 min ( all) and then increased by 14% and 46% at 2 h (frontal lobe, ; thalamus, ) and by 29% and 68% at 6 h (frontal lobe, ; thalamus, ) after acute intake. Mean diffusivity decreased significantly in both the frontal lobe and the thalamus at various stages. However, fractional anisotropy decreased only in the frontal lobe, with no detectable change in the thalamus. This demonstrates that DKI possesses sufficient sensitivity for tracking pathophysiological changes at various stages associated with acute alcohol intoxication and may provide additional information that may be missed by conventional DTI parameters.