MicroRNA Expression Signature in Human Calcific Aortic Valve Disease

Table 3

The pathways affected by upregulation of specific microRNAs in CAVD.

KEGG pathway	value	Genes	miRNAs
p53 signaling pathway		11	2
HIF-1 signaling pathway	0.00023	10	2
Valine, leucine, and isoleucine biosynthesis	0.00227	1	1
ErbB signaling pathway	0.003959	5	1
Cell cycle	0.003959	10	2
mTOR signaling pathway	0.004909	6	1
MAPK signaling pathway	0.005193	15	2
PI3K-Akt signaling pathway	0.005193	17	2
Wnt signaling pathway	0.008586	10	1
Synthesis and degradation of ketone bodies	0.009366	2	1
TGF-beta signaling pathway	0.021216	7	1
Basal transcription factors	0.029417	4	1
Glycerophospholipid metabolism	0.030271	8	1
Hypertrophic cardiomyopathy (HCM)	0.030271	6	1
Focal adhesion	0.030271	11	2
Circadian rhythm	0.030848	3	1
Mismatch repair	0.034518	2	1
Lysine degradation	0.038471	4	1
Butanoate metabolism	0.038615	3	1

Specific types of cancers and infections were not included.