miRNAs in Prediction of Prognosis in Clear Cell Renal Cell Carcinoma

Table 1

Studies on miRNAs predicting the prognosis of ccRCC.

miRNA	Ref	Findings
miR-125b	[16]	An independent adverse prognostic factor for the recurrence and survival
miR-124-3	[17]	Its methylation level was associated with the occurrence of distant metastasis, high pathological grade, and increased risk of disease recurrence
miR-30a	[19]	High level predicts longer metastasis-free survival time, an independent predictor of distant metastasis
miR-122 miR-514	[22]	Involve in tumor recurrence after nephrectomy
miR-194	[10]	High level predicts longer DFS and OS, a prognostic factor of OS for tumors ≤ 4 cm
mir-210	[23]	High level predicts shorter DFS and OS for larger tumors (>4 cm)
miR-630	[26]	High level predicts shorter OS
miR-23B/27B cluster	[14]	Low level predicts disease progression and poor survival
miR-29b	[15]	High level predicts advanced TNM stage and short OS
miR-27a-3p	[18]	High level predicts the recurrence of ccRCC in M0 patients
miR-646	[20]	High level predicts longer metastasis-free survival time; and low level predicts ccRCC metastasis
miR-30c	[21]	Involved in metastasis
miR-126	[9]	High level predicts prolonged OS for larger tumors (>4 cm)
miR-203	[24]	Low level predicts poorer OS
miR-217	[27]	Low level predicts poorer survival
miR-187	[28]	Low level predicts advanced tumor grade and stage and poorer 5-year survival
miR-129-3p	[29]	Low level predicts short DFS and OS

ccRCC, clear cell renal cell carcinoma; DFS, disease-free survival; OS, overall survival; TNM, tumor-node-metastasis.