Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2017 (2017), Article ID 4862861, 9 pages
https://doi.org/10.1155/2017/4862861
Research Article

L-Glutamine Supplementation Alleviates Constipation during Late Gestation of Mini Sows by Modifying the Microbiota Composition in Feces

Laboratory Animal and Comparative Medicine, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China

Correspondence should be addressed to Hongyan Chen; nc.ca.irvh@nehcyh

Received 27 October 2016; Accepted 20 February 2017; Published 12 March 2017

Academic Editor: Jiangke Yang

Copyright © 2017 Yuanyuan Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Chassard, M. Dapoigny, K. P. Scott et al., “Functional dysbiosis within the gut microbiota of patients with constipated-irritable bowel syndrome,” Alimentary Pharmacology and Therapeutics, vol. 35, no. 7, pp. 828–838, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. U. C. Ghoshal, R. Shukla, U. Ghoshal, K.-A. Gwee, S. C. Ng, and E. M. M. Quigley, “The gut microbiota and irritable bowel syndrome: friend or foe?” International Journal of Inflammation, vol. 2012, Article ID 151085, 13 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. Z.-L. Dai, X.-L. Li, P.-B. Xi, J. Zhang, G. Wu, and W.-Y. Zhu, “Metabolism of select amino acids in bacteria from the pig small intestine,” Amino Acids, vol. 42, no. 5, pp. 1597–1608, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. Ö. C. O. Umu, J. A. Frank, J. U. Fangel et al., “Resistant starch diet induces change in the swine microbiome and a predominance of beneficial bacterial populations,” Microbiome, vol. 3, no. 1, article 16, 2015. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Shakeri, E. Oskoueian, P. Najafi, and M. Ebrahimi, “Impact of glutamine in drinking water on performance and intestinal morphology of broiler chickens under high stocking density,” İstanbul Üniversitesi Veteriner Fakültesi Dergisi, vol. 42, no. 1, pp. 51–56, 2015. View at Google Scholar
  6. C. De Filippo, D. Cavalieri, M. Di Paola et al., “Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 33, pp. 14691–14696, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. S. B. Catherine, C. M. Kennedy, A. M. Turcea, S. S. Rao, and I. E. Nygaard, “Constipation in pregnancy—prevalence, symptoms, and risk factors,” Obstetrics & Gynecology, vol. 110, pp. 1351–1357, 2007. View at Google Scholar
  8. C. H. Choi and S. K. Chang, “Alteration of gut microbiota and efficacy of probiotics in functional constipation,” Journal of Neurogastroenterology and Motility, vol. 21, no. 1, pp. 4–7, 2015. View at Publisher · View at Google Scholar · View at Scopus
  9. P. S. Karen, S. W. Gratz, P. O. Sheridan, H. J. Flint, and S. H. Duncan, “The influence of diet on the gut microbiota,” Pharmacological Research, vol. 69, pp. 52–60, 2013. View at Google Scholar
  10. T. K. Weber, M. S. Toporovski, S. Tahan, C. B. Neufeld, and M. B. De Morais, “Dietary fiber mixture in pediatric patients with controlled chronic constipation,” Journal of Pediatric Gastroenterology and Nutrition, vol. 58, no. 3, pp. 297–302, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. W. K. Ren, S. Chen, J. Yin et al., “Dietary arginine supplementation of mice alters the microbial population and activates intestinal innate immunity,” Journal of Nutrition, vol. 144, no. 6, pp. 988–995, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. C. C. Xu, S. F. Yang, L. H. Zhu et al., “Regulation of N-acetyl cysteine on gut redox status and major microbiota in weaned piglets,” Journal of Animal Science, vol. 92, no. 4, pp. 1504–1511, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Chamorro, C. de Blas, G. Grant, I. Badiola, D. Menoyo, and R. Carabaño, “Effect of dietary supplementation with glutamine and a combination of glutamine-arginine on intestinal health in twenty-five-day-old weaned rabbits,” Journal of Animal Science, vol. 88, no. 1, pp. 170–180, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Wada, K. Sato, R. Ohta et al., “Ingestion of low dose pyroglutamyl leucine improves dextran sulfate sodium-induced colitis and intestinal microbiota in mice,” Journal of Agricultural and Food Chemistry, vol. 61, no. 37, pp. 8807–8813, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. G. Wu, Z. Wu, Z. Dai et al., “Dietary requirements of “nutritionally non-essential amino acids” by animals and humans,” Amino Acids, vol. 44, no. 4, pp. 1107–1113, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Yoshida, Y. Naomoto, K. Shigemitsu et al., “Amino acid signaling in the intestine: the roles of glutamine, leucine and arginine,” Kawasaki Medical Journal, vol. 40, no. 2, pp. 55–60, 2014. View at Google Scholar
  17. C. Domeneghini, A. Di Giancamillo, S. Arrighi, and G. Bosi, “Gut-trophic feed additives and their effects upon the gut structure and intestinal metabolism. State of the art in the pig, and perspectives towards humans,” Histology and Histopathology, vol. 21, no. 1–3, pp. 273–283, 2006. View at Google Scholar · View at Scopus
  18. K. Forchhammer, “Glutamine signalling in bacteria,” Frontiers in Bioscience, vol. 12, no. 1, pp. 358–370, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. Z.-L. Dai, X.-L. Li, P.-B. Xi, J. Zhang, G. Wu, and W.-Y. Zhu, “L-Glutamine regulates amino acid utilization by intestinal bacteria,” Amino Acids, vol. 45, no. 3, pp. 501–512, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. S. P. Wang, F. Blachier, F. Zhao, and Y. L. Yin, “Intestinal microbiota: development, metabolism and functions,” Journal of Food, Agriculture and Environment, vol. 9, no. 2, pp. 121–129, 2011. View at Google Scholar · View at Scopus
  21. G. Wu, “Amino acids: metabolism, functions, and nutrition,” Amino Acids, vol. 37, no. 1, pp. 1–17, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. K. Naumann and R. Bassler, Methodenbuch des Verbandes deutscher landwirtschaftlicher Untersuchungs- und Forschungsanstalten. BD, III: Die Chemische Untersuchung von Futtermitteln, VDLUFA, Darmstadt, Germany, 1997.
  23. W. Ren, Y. Li, X. Yu et al., “Glutamine modifies immune responses of mice infected with porcine circovirus type 2,” British Journal of Nutrition, vol. 110, no. 6, pp. 1053–1060, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Oliviero, M. Heinonen, A. Valros, and O. Peltoniemi, “Environmental and sow-related factors affecting the duration of farrowing,” Animal Reproduction Science, vol. 119, no. 1-2, pp. 85–91, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. T. Magoč and S. L. Salzberg, “FLASH: fast length adjustment of short reads to improve genome assemblies,” Bioinformatics, vol. 27, no. 21, pp. 2957–2963, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. J. G. Caporaso, J. Kuczynski, J. Stombaugh et al., “QIIME allows analysis of high-throughput community sequencing data,” Nature Methods, vol. 7, no. 5, pp. 335–336, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. R. C. Edgar, B. J. Haas, J. C. Clemente, C. Quince, and R. Knight, “UCHIME improves sensitivity and speed of chimera detection,” Bioinformatics, vol. 27, no. 16, pp. 2194–2200, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. R. C. Edgar, “UPARSE: highly accurate OTU sequences from microbial amplicon reads,” Nature Methods, vol. 10, no. 10, pp. 996–998, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. Q. Wang, G. M. Garrity, J. M. Tiedje, and J. R. Cole, “Naïve Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy,” Applied and Environmental Microbiology, vol. 73, no. 16, pp. 5261–5267, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. R. C. Edgar, “MUSCLE: multiple sequence alignment with high accuracy and high throughput,” Nucleic Acids Research, vol. 32, no. 5, pp. 1792–1797, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. C. Hsieh, “Treatment of constipation in older adults,” American Family Physician, vol. 72, no. 11, pp. 2277–2284, 2005. View at Google Scholar · View at Scopus
  32. G. Cullen and D. O'Donoghue, “Constipation and pregnancy,” Best Practice and Research: Clinical Gastroenterology, vol. 21, no. 5, pp. 807–818, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. E. Derbyshire, J. Davies, V. Costarelli, and P. Dettmar, “Diet, physical inactivity and the prevalence of constipation throughout and after pregnancy,” Maternal & Child Nutrition, vol. 2, no. 3, pp. 127–134, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. C. Oliviero, Successful farrowing in sows [Dissertation], University of Helsinki, 2010.
  35. G. Wu, F. W. Bazer, G. A. Johnson et al., “TRIENNIAL GROWTH SYMPOSIUM: important roles for l-glutamine in swine nutrition and production,” Journal of Animal Science, vol. 89, no. 7, pp. 2017–2030, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. P. H. R. F. Campos, B. A. N. Silva, J. L. Donzele, R. F. M. Oliveira, and E. F. Knol, “Effects of sow nutrition during gestation on within-litter birth weight variation: a review,” Animal, vol. 6, no. 5, pp. 797–806, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. J. T. Self, T. E. Spencer, G. A. Johnson, J. Hu, F. W. Bazer, and G. Wu, “Glutamine synthesis in the developing porcine placenta,” Biology of Reproduction, vol. 70, no. 5, pp. 1444–1451, 2004. View at Publisher · View at Google Scholar · View at Scopus
  38. G. Wu, T. L. Ott, D. A. Knabe, and F. W. Bazer, “Amino acid composition of the fetal pig,” Journal of Nutrition, vol. 129, no. 5, pp. 1031–1038, 1999. View at Google Scholar · View at Scopus
  39. M. Blaut, M. D. Collins, G. W. Welling, J. Doré, J. Van Loo, and W. De Vos, “Molecular biological methods for studying the gut microbiota: the EU human gut flora project,” British Journal of Nutrition, vol. 87, supplement 2, pp. S203–S211, 2002. View at Publisher · View at Google Scholar · View at Scopus
  40. A. M. Rowan, P. J. MvghqOUGHAN, M. N. Wilson, K. Maher, and C. Tasman-jones, “Comparison of the ileal and faecal digestibility of dietary amino acids in adult humans and evaluation of the pig as a model animal for digestion studies in man,” British Journal of Nutrition, vol. 71, no. 1, pp. 29–42, 1994. View at Publisher · View at Google Scholar · View at Scopus
  41. X. Pang, X. Hua, Q. Yang et al., “Inter-species transplantation of gut microbiota from human to pigs,” The ISME Journal, vol. 1, no. 2, pp. 156–162, 2007. View at Publisher · View at Google Scholar · View at Scopus
  42. P. L. Torey, The Swine Intestinal Microbiota: Localized Adaptations and Responses to in-Feed Antibiotics, Iowa State University, Ames, Iowa, USA, 2012.
  43. M. Othman, R. Agüero, and H. C. Lin, “Alterations in intestinal microbial flora and human disease,” Current Opinion in Gastroenterology, vol. 24, no. 1, pp. 11–16, 2008. View at Publisher · View at Google Scholar · View at Scopus
  44. L. Zhu, W. Liu, R. Alkhouri et al., “Structural changes in the gut microbiome of constipated patients,” Physiological Genomics, vol. 46, no. 18, pp. 679–686, 2014. View at Publisher · View at Google Scholar · View at Scopus
  45. R. E. Ley, M. Hamady, C. Lozupone et al., “Evolution of mammals and their gut microbes,” Science, vol. 320, no. 5883, pp. 1647–1651, 2008. View at Publisher · View at Google Scholar · View at Scopus
  46. Z.-M. Feng, T.-J. Li, L. Wu, D.-F. Xiao, F. Blachier, and Y.-L. Yin, “Monosodium L-glutamate and dietary fat differently modify the composition of the intestinal microbiota in growing pigs,” Obesity Facts, vol. 8, no. 2, pp. 87–100, 2015. View at Publisher · View at Google Scholar · View at Scopus
  47. M. A. Pourhoseingholi, S. A. Kaboli, A. Pourhoseingholi et al., “Obesity and functional constipation; a community-based study in Iran,” Journal of Gastrointestinal and Liver Diseases, vol. 18, no. 2, pp. 151–155, 2009. View at Google Scholar · View at Scopus
  48. K. Y. Choi, T. K. Lee, and W. J. Sul, “Metagenomic analysis of chicken gut microbiota for improving metabolism and health of chickens—a review,” Asian-Australasian Journal of Animal Sciences, vol. 28, no. 9, pp. 1217–1225, 2015. View at Publisher · View at Google Scholar · View at Scopus
  49. R. B. Guevarra, J. Kim, S. G. Nguyen, and T. Unno, “Comparison of fecal microbial communities between white and black pigs,” Journal of Applied Biological Chemistry, vol. 58, no. 4, pp. 369–375, 2015. View at Publisher · View at Google Scholar · View at Scopus
  50. R. Lamendella, J. W. Santo Domingo, S. Ghosh, J. Martinson, and D. B. Oerther, “Comparative fecal metagenomics unveils unique functional capacity of the swine gut,” BMC Microbiology, vol. 11, article 103, 2011. View at Publisher · View at Google Scholar · View at Scopus
  51. S. Tachon, B. Lee, and M. L. Marco, “Diet alters probiotic Lactobacillus persistence and function in the intestine,” Environmental Microbiology, vol. 16, no. 9, pp. 2915–2926, 2014. View at Publisher · View at Google Scholar · View at Scopus
  52. D. Gevers, S. Kugathasan, L. A. Denson et al., “The treatment-naive microbiome in new-onset Crohn's disease,” Cell Host and Microbe, vol. 15, no. 3, pp. 382–392, 2014. View at Publisher · View at Google Scholar · View at Scopus
  53. U. Gophna, T. Konikoff, and H. Bjørn Nielsen, “Oscillospira and related bacteria—from metagenomic species to metabolic features,” Environmental Microbiology, 2017. View at Publisher · View at Google Scholar
  54. S. Tims, Mining Microbiota Signatures in Human Intestinal Tract Metagenomes, Wageningen University, Gelderland, Netherlands, 2016.
  55. T. Konikoff and U. Gophna, “Oscillospira: a central, enigmatic component of the human gut microbiota,” Trends in Microbiology, vol. 24, no. 7, pp. 523–524, 2016. View at Publisher · View at Google Scholar · View at Scopus
  56. N. Keren, F. M. Konikoff, Y. Paitan et al., “Interactions between the intestinal microbiota and bile acids in gallstones patients,” Environmental Microbiology Reports, vol. 7, no. 6, pp. 874–880, 2015. View at Publisher · View at Google Scholar · View at Scopus