Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research
Table 2
This table summarizes the thrombolytic drugs, details of clinical trials completed in AIS, route (i.v.: intravenous; i.a.: intra-arterial), phases, number of patients enrolled, and clinical trial number.
Summary of thrombolytic drug trials
Drug
Dose
Time window
Phase
Number of patients
Clinical trial number
Citation
Reteplase + abciximab
0.25 mg/kg bolus of abciximab i.v. + 0.125 mcg/kg/min infusion for 12 hours i.a. reteplase in boluses of 0.25 units (5 minutes) proximal to the thrombus + incremental doses