BioMed Research International

Review Article

CD147 as a Novel Prognostic Biomarker for Hepatocellular Carcinoma: A Meta-Analysis

Table 1

Main characteristics of enrolled studies.
First authorTimeCountryAgeNumber of patientsSurvival resultsTest methodTumor typesHRFollow-up timeCancer stageExpression
location		Cut-off valueNOS score
Li2005China24–6951DFSIHCHCCUnivariate5–90 monthsNACell surfacePositive: more than 10% of cells stained7
Zhang2006China48.52 ± 9.6082RFSIHCHCCMultivariate1–45 monthsTNMI-Cell surfacePositive: more than 10% of cells stained7
Zhang2007China24–66111RFSIHCHCCMultivariate1–63 monthsTNMI-Cell surfaceNA7
Wang2012China28–65272OS, MSTIHCHCCUnivariateNATNMI-Cell surfacePositive: scores ≥ 2 were positive7
Li2010China15–6583OS, MSTIHCHCCUnivariate1–101 monthsTNMI-Cell surfacePositive: more than 10%6
Luo2011ChinaNA180RFSIHCHCCUnivariate0–12 monthsTNMI-Cell surfacePositive: more than 5%6
Zhang2014China24–6651OS, MSTIHCHCCUnivariate2–60 monthsTNMI-Cell surfaceNA6
Zhu2015China31–7650OSIHCHCCMultivariate0–48 monthsNACell surfacePositive: more than 5%7
MST: median survival time; : the research is liver transplantation; scores: The positive cells were classified into 4 grades on the basis of the percentage of the positive cells: the number of the cells below 5% was zero score, 6%–25% was 1 score, 26%–50% was 2 score, and higher than 51% was 3 score; second the positive cells were classified into 4 grades on the basis of intensity of color: colorless was zero score, yellow was 1 score, light brown was 2 score, and deep brown was 3 score. Then the two kinds of scores were added: the score which was lower than 1 was negative and that which was higher than 2 was positive.