CD147 as a Novel Prognostic Biomarker for Hepatocellular Carcinoma: A Meta-Analysis

Table 3

Results of subgroups analysis.

	OS						DFS/RFS
	Number	HR (95% CI)		(%)		Model	Number	HR (95% CI)		(%)		Model
Total	4						4
Univariate/Multivariate
Multivariate	1	0.5 (0.26, 0.96)			0.04		2	7.72 (2,86, 20.86)	0.84	0	<0.0001	Fixed
Univariate	3	2.21 (1.44, 3.38)	0.15	48	0.0003	Fixed	2	2.08 (1.01, 4.26)	0.75	0	0.05	Fixed
Follow-up time
More than 5 years	2	1.75 (0.57, 5.34)	0.1	63	0.33	Random	2	2.10 (0.84, 5.23)	0.46	0	0.11	Fixed
Less than 5 years	1	0.50 (0.26, 0.96)			0.04		2	4.40 (2,07, 9.36)	0.11	60	0.0001	Fixed
Liver transplantation
Yes	0						2	4.40 (2.07, 9.36)	0.11	60	0.0001	Fixed
No	4	1.35 (0.56, 3.29)	0.0006	83	0.51	Random	2	2.10 (0.84, 5.23)	0.46	0	0.11	Fixed
Cut-off value
More than 10% of cells stained	1	2.80 (1.41, 5.56)			0.03		2	3.81 (0.92, 15.76)	0.05	75	0.07	Random
Less than 10% of cells stained	1	0.50 (0.26, 0.96)			0.04		2	2.64 (0.96, 7.25)	0.56	0	0.06	Fixed

means the heterogeneity of value.