Role of Transient Receptor Potential Vanilloid 1 in Electroacupuncture Analgesia on Chronic Inflammatory Pain in Mice

Figure 4

Schematic illustration of possible mechanisms of TRPV1 in CFA-induced chronic inflammatory pain in mice model. We showed that TRPV1 is an important receptor in mice chronic inflammatory pain model. The activation of TRPV1 increases the expression of pPKA, pPI3K, pPKC, pAkt, and pmTOR. Furthermore, pERK, pp38, pJNK, pNFκB, and pCREB are also increased. Moreover, nociceptive Nav1.7 and Nav1.8 are increased for pain conduction in both peripheral DRG and central SC. Inflammatory factors such as GFAP, S100B, and RAGE are also involved in this process.