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BioMed Research International
Volume 2017, Article ID 5125980, 10 pages
Research Article

The Effects of Long-Term Chaetomellic Acid A Administration on Renal Function and Oxidative Stress in a Rat Model of Renal Mass Reduction

1Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal
2Department of Therapeutic and Diagnostic Technologies, Polytechnic Institute of Bragança (IPB), Bragança, Portugal
3Department of Biology and Environment, School of Life Science and Environment, UTAD, Vila Real, Portugal
4Center for the Research and Technology of Agro-Environmental and Biological Science (CITAB), UTAD, Vila Real, Portugal
5Department of Chemistry, School of Life Science and Environment, UTAD, Vila Real, Portugal
6Chemistry Center of Vila Real (CQVR), UTAD, Vila Real, Portugal
7Department of Mathematics, School of Science and Technology, UTAD, Vila Real, Portugal
8Department of Zootechnic, School of Agrarian and Veterinary Sciences, UTAD, Vila Real, Portugal

Correspondence should be addressed to Maria João Pires; tp.datu@pmoaoj

Received 30 August 2016; Revised 4 November 2016; Accepted 7 November 2016; Published 23 February 2017

Academic Editor: Kazim Husain

Copyright © 2017 António Nogueira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. This study aimed to evaluate the effect of chronic treatment with chaetomellic acid A (CAA) on oxidative stress and renal function in a model of renal mass reduction. Methods. Male Wistar rats were subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been divided into four experimental groups: RMR: RMR rats without treatment ; RMR + CAA: RMR rats treated with CAA ; SO: SO rats without treatment ; and SO + CAA: SO rats treated with CAA . CAA was intraperitoneally administered in a dose of 0.23 µg/Kg three times a week for six months. Results. RMR was accompanied by a significant reduction in catalase and glutathione reductase (GR) activity and a decrease in reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio. CAA administration significantly increased catalase and GR activity and increased GSH/GSSG ratio, but no significant difference between the treated and nontreated groups was found in this ratio. No significant differences were found between the RMR groups in any of the parameters of renal function. However, CAA administration slightly improves some parameters of renal function. Conclusions. These data suggest that CAA could attenuate 5/6 RMR-induced oxidative stress.