The Effects of Long-Term Chaetomellic Acid A Administration on Renal Function and Oxidative Stress in a Rat Model of Renal Mass Reduction
Table 2
Body weight, haematocrit, and renal function parameters.
Parameter
Group
Basal
Month 1
Month 2
Month 3
Month 4
Month 5
Month 6
Body weight (g)
SO ()
392 ± 10
458 ± 12
484 ± 13
506 ± 13
539 ± 15
551 ± 16
561 ± 16
SO + CAA ()
371 ± 5
435 ± 5
462 ± 6
487 ± 7
524 ± 9
534 ± 10
550 ± 10
RMR ()
370 ± 11
412 ± 10
444 ± 13
478 ± 14
513 ± 14
517 ± 14
516 ± 13
RMR + CAA ()
374 ± 7
407 ± 10
446 ± 10
463 ± 11
491 ± 10
494 ± 12
503 ± 12
Haematocrit (%)
SO ()
49.9 ± 0.5
55.4 ± 0.6
54.3 ± 0.6
53.0 ± 0.7
54.9 ± 0.5
54.7 ± 0.5
54.8 ± 0.7
SO + CAA ()
48.2 ± 0.6
54.9 ± 0.8
54.0 ± 0.7
55.1 ± 0.7
53.4 ± 0.7
49.8 ± 1.6
53.0 ± 0.7
RMR ()
49.0 ± 0.5
49.3 ± 0.5
49.4 ± 0.7
49.2 ± 0.8
48.9 ± 0.9
46.2 ± 0.9
43.5 ± 1.7
RMR + CAA ()
48.2 ± 0.6
51.8 ± 0.5
52.5 ± 0.7
51.4 ± 0.8
51.3 ± 1.2
45.9 ± 1.2
46.1 ± 2.0
Urine specific gravity
SO ()
1.035 ± 0.002
1.035 ± 0.002
1.032 ± 0.002
1.035 ± 0.002
1.037 ± 0.001
1.039 ± 0.001
1.039 ± 0.001
SO + CAA ()
1.033 ± 0.002
1.038 ± 0.0010
1.035 ± 0.001
1.037 ± 0.001
1.038 ± 0.001
1.041 ± 0.000
1.040 ± 0.000
RMR ()
1.029 ± 0.002
1.027 ± 0.002
1.024 ± 0.002
1.025 ± 0.002
1.025 ± 0.001
1.027 ± 0.001
1.026 ± 0.001
RMR + CAA ()
1.029 ± 0.004
1.032 ± 0.002
1.030 ± 0.002
1.028 ± 0.002
1.028 ± 0.002
1.031 ± 0.002
1.030 ± 0.002
Urinary flow (ml/hour)
SO ()
0.60 ± 0.06
0.61 ± 0.06
0.74 ± 0.07
0.60 ± 0.06
0.67 ± 0.05
0.69 ± 0.04
0.64 ± 0.04
SO + CAA ()
0.57 ± 0.04
0.53 ± 0.05
0.54 ± 0.04
0.50 ± 0.05
0.72 ± 0.05
0.60 ± 0.03
0.56 ± 0.05
RMR ()
0.78 ± 0.05
1.01 ± 0.06
1.11 ± 0.09
1.09 ± 0.08
1.51 ± 0.12
1.66 ± 0.12
1.76 ± 0.14
RMR + CAA ()
0.76 ± 0.20
0.80 ± 0.07
0.88 ± 0.09
0.92 ± 0.09
1.10 ± 0.10
1.43 ± 0.18
1.49 ± 0.20
Phosphorus (mg/dl)
SO ()
5.97 ± 0.10
6.31 ± 0.15
6.01 ± 0.13
5.56 ± 0.20
6.02 ± 0.20
5.68 ± 0.10
6.39 ± 0.28
SO + CAA ()
6.13 ± 0.15
6.55 ± 0.24
5.85 ± 0.20
6.01 ± 0.18
6.11 ± 0.17
5.49 ± 0.17
6.07 ± 0.28
RMR ()
5.69 ± 0.12
6.22 ± 0.21
5.09 ± 0.16
5.48 ± 0.20
5.97 ± 0.14
6.05 ± 0.11
8.21 ± 0.49
RMR + CAA ()
6.08 ± 0.13
6.78 ± 0.15
5.87 ± 0.12
5.94 ± 0.19
5.75 ± 0.34
5.89 ± 0.66
7.48 ± 0.48
Potassium (mmol/l)
SO ()
5.44 ± 0.13
4.82 ± 0.09
5.07 ± 0.10
4.69 ± 0.10
5.55 ± 0.13
5.34 ± 0.11
4.81 ± 0.10
SO + CAA ()
5.33 ± 0.08
5.13 ± 0.13
5.24 ± 0.12
5.03 ± 0.10
5.08 ± 0.14
5.20 ± 0.09
4.51 ± 0.18
RMR ()
5.17 ± 0.07
5.32 ± 0.05
5.00 ± 0.13
5.05 ± 0.11
5.16 ± 0.09
5.28 ± 0.12
5.28 ± 0.14
RMR + CAA ()
5.40 ± 0.05
5.65 ± 0.13
5.38 ± 0.18
4.92 ± 0.16
4.85 ± 0.21
5.27 ± 0.16
4.85 ± 0.14
BUN (mg/dl)
SO ()
28.8 ± 1.1
56.5 ± 2.3
30.6 ± 1.8
34.3 ± 0.7
37.8 ± 0.8
42.9 ± 1.3
40.4 ± 1.9
SO + CAA ()
28.4 ± 1.1
35.6 ± 1.4
34.0 ± 1.3
34.8 ± 1.7
34.3 ± 1.0
50.2 ± 2.1
45.7 ± 2.0
RMR ()
26.1 ± 1.1
70.8 ± 2.9
91.2 ± 5.1
63.9 ± 4.0
66.5 ± 3.5
90.9 ± 6.7
146.7 ± 20.2
RMR + CAA ()
28.0 ± 1.8
66.2 ± 2.0
96.3 ± 3.6
56.4 ± 4.8
63.9 ± 4.0
76.0 ± 6.0
95.9 ± 14.2
Plasma creatinine (mg/dl)
SO ()
0.68 ± 0.02
0.54 ± 0.01
0.61 ± 0.01
0.70 ± 0.02
0.74 ± 0.02
0.74 ± 0.02
0.74 ± 0.02
SO + CAA ()
0.69 ± 0.02
0.90 ± 0.05
0.60 ± 0.02
0.64 ± 0.02
0.67 ± 0.02
0.72 ± 0.01
0.75 ± 0.05
RMR ()
0.68 ± 0.02
0.98 ± 0.04
0.78 ± 0.04
0.92 ± 0.06
0.92 ± 0.03
1.06 ± 0.07
1.69 ± 0.23
RMR + CAA ()
0.74 ± 0.02
1.01 ± 0.03
0.85 ± 0.03
0.91 ± 0.04
0.95 ± 0.03
1.00 ± 0.05
1.28 ± 0.18
Proteinuria (g/day)
SO ()
0.098 ± 0.005
0.108 ± 0.007
0.108 ± 0.005
0.093 ± 0.008
0.100 ± 0.004
0.106 ± 0.006
0.105 ± 0.006
SO + CAA ()
0.095 ± 0.009
0.130 ± 0.012
0.110 ± 0.008
0.096 ± 0.008
0.112 ± 0.007
0.107 ± 0.005
0.117 ± 0.008
RMR ()
0.110 ± 0.012
0.194 ± 0.014
0.326 ± 0.063
0.578 ± 0.159
1.117 ± 0.286
1.997 ± 0.363
3.167 ± 0.410
RMR + CAA ()
0.088 ± 0.010
0.179 ± 0.017
0.290 ± 0.047
0.433 ± 0.132
0.688 ± 0.210
1.360 ± 0.462
2.467 ± 0.758
Creatinine clearance (ml/min)
SO ()
1.67 ± 0.17
1.55 ± 0.07
1.62 ± 0.09
1.57 ± 0.09
1.68 ± 0.07
1.84 ± 0.08
1.56 ± 0.04
SO + CAA ()
1.55 ± 0.09
0.90 ± 0.06
1.42 ± 0.06
1.44 ± 0.061
1.71 ± 0.03
1.60 ± 0.05
1.45 ± 0.09
RMR ()
1.70 ± 0.11
0.77 ± 0.04
1.09 ± 0.07
1.10 ± 0.07
1.14 ± 0.06
1.27 ± 0.07
0.73 ± 0.10
RMR + CAA ()
1.63 ± 0.41
0.79 ± 0.04
0.97 ± 0.05
1.09 ± 0.05
1.13 ± 0.07
1.28 ± 0.04
0.92 ± 0.11
Significant differences compared to SO;significant differences compared to SO + CAA;significant differences compared to RMR. Significant differences compared to basal ();significant differences compared to first month (Month 1) ();significant differences compared to second month (Month 2) ();significant differences compared to third month (Month 3) ();significant differences compared to fourth month (Month 4) ();significant differences compared to fifth month (Month 5) ().
