Computational Exploration for Lead Compounds That Can Reverse the Nuclear Morphology in Progeria

Table 1

Common feature pharmacophore results as generated by the HipHop.

Hypo number	Features	Rank	Direct Hit	Partial Hit	Max fit
1	RHHDA	26.307	1111	0000	4
2	RHHDA	25.624	1111	0000	4
3	ZHHDA	25.574	1111	0000	4
4	RHHDA	25.352	1111	0000	4
5	RHHDA	25.352	1111	0000	4
6	HHHDA	24.569	1111	0000	4
7	RHHDA	24.450	1111	0000	4
8	HHHDA	24.362	1111	0000	4
9	ZHHDA	24.290	1111	0000	4
10	RHAA	24.069	1111	0000	4

R: ring aromatic, H: hydrophobic, HD: hydrogen bond donor, A: hydrogen bond acceptor, Z: zinc binder.