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BioMed Research International
Volume 2017, Article ID 5312813, 6 pages
Review Article

Angiogenesis Dysregulation in Psoriatic Arthritis: Molecular Mechanisms

1Rheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia Medical School, Foggia, Italy
2Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy
3National Cancer Institute “Giovanni Paolo II”, Bari, Italy

Correspondence should be addressed to Francesco Paolo Cantatore; ti.gfinu@erotatnac.oloapocsecnarf

Received 1 April 2017; Revised 5 June 2017; Accepted 13 June 2017; Published 19 July 2017

Academic Editor: Ruben Queiro-Silva

Copyright © 2017 Francesco Paolo Cantatore et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


There is evidence that psoriatic arthritis is closely linked to angiogenesis. Morphological changes described in blood vessels of psoriatic arthritis joints suggest the presence of a dysregulated angiogenesis resulting in the formation of immature vessels. Even if the reason of this inefficient angiogenesis is still unclear, an imbalance between angiogenic and antiangiogenic factors is probably responsible for inducing a dysregulated angiogenesis in psoriatic arthritis, which seems to be involved in its pathogenesis and clinical features. Nevertheless, among chronic arthritides, while angiogenesis in rheumatoid arthritis has been largely studied with a great amount of literature data, limited data on angiogenesis role in psoriatic arthritis are available. This review article is focused on current knowledge on the mechanisms responsible for dysregulated angiogenesis in psoriatic arthritis.