Overhydroxylation of Lysine of Collagen Increases Uterine Fibroids Proliferation: Roles of Lysyl Hydroxylases, Lysyl Oxidases, and Matrix Metalloproteinases

Figure 6

Expression of LOX gene in UF and normal myometrial tissues. (a) Quantitative real-time RT-PCR analysis shows a significant increase in the expression of LOX gene in fibroid tissues compared with the normal myometrial tissues (). (b) Expression of pro-LOX and active LOX proteins in fibroids and normal myometrial tissues. (c) Quantification of the total and active LOX proteins in fibroids and normal myometrial tissues. The bands corresponding to the total and active LOX proteins were analyzed by densitometric scan, using β-actin for normalization. indicates a significant difference ().

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