BioMed Research International / 2017 / Article / Tab 5

Research Article

High Prevalence of Leptotrichia amnionii, Atopobium vaginae, Sneathia sanguinegens, and Factor 1 Microbes and Association of Spontaneous Abortion among Korean Women

Table 5

High-risk microbial patterns associated with spontaneous abortion and induced abortion.

MicrobiotaGroupsNonabortion (%)Spontaneous abortion
(%)
Induced abortion
(%)
Univariate (ORs, 95% CI)Multivariate (ORs, 95% CI)
Spontaneous abortionInduced abortionSpontaneous abortionInduced abortion

Factor 1Low29 (80.6)11 (47.8)60 (68.2)1 (ref.)1 (ref.)1 (ref.)1 (ref.)
High7 (19.4)12 (52.2)28 (31.8)4.51 (1.41–14.5)1.93 (0.76–4.95)16.4 (1.88–42.5)2.63 (0.87–7.92)
Atopobium vaginaeLow29 (80.6)10 (43.5)61 (69.3)1 (ref.)1 (ref.)1 (ref.)1 (ref.)
High7 (19.4)13 (56.5)27 (30.7)5.38
(1.68–17.29)
1.83
(0.72–4.7)
11.27
(1.57–81.00)
2.42
(0.82–7.16)
Leptotrichia amnioniiLow32 (88.9)15 (65.2)63 (74.9)1 (ref.)1 (ref.)1 (ref.)1 (ref.)
High4 (11.1)8 (34.8)25 (28.1)4.26
(1.11–16.42)
3.17
(1.02–9.91)
11.47
(1.22–107.94)
4.17
(1.05–16.49)
Sneathia sanguinegensLow32 (88.9)14 (60.9)74 (84.1)1 (ref.)1 (ref.)1 (ref.)1 (ref.)
High4 (11.1)9 (39.1)14 (15.9)5.14 (1.35–19.54)1.51
(0.46–4.95)
6.89
(1.07–44.33)
1.41
(0.39–5.05)
Megasphaera spp.Low31 (86.1)15 (65.2)71 (80.7)1 (ref.)1 (ref.)1 (ref.)1 (ref.)
High5 (13.9)8 (34.8)17 (19.3)3.30
(0.92–11.85)
1.48
(0.5–4.38)
4.99
(0.81–30.82)
2.61
(0.71–9.57)
Gardnerella vaginalisLow29 (80.6)14 (60.8)59 (67.1)1 (ref.)1 (ref.)1 (ref.)1 (ref.)
High7 (19.4)9 (39.2)29 (32.9)2.66
(0.82–8.63)
2.03
(0.8–5.2)
1.16
(0.16–8.32)
2.47
(0.83–7.32)

ORs, 95% CIs were calculated by multivariate logistic regression after controlling for age, menopause, BMI, smoking, alcohol, and HPV. The low- and high-abundance microbiota were defined by the low tertile and high tertile, respectively.

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