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BioMed Research International
Volume 2017, Article ID 5437139, 12 pages
Research Article

Oxidative Stress Induced by Polymyxin E Is Involved in Rapid Killing of Paenibacillus polymyxa

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China

Correspondence should be addressed to Zhiliang Yu; nc.ude.tujz@uylz and Juanping Qiu; nc.ude.tujz@gnipjuiq

Received 21 November 2016; Accepted 19 January 2017; Published 22 February 2017

Academic Editor: Swaran J. S. Flora

Copyright © 2017 Zhiliang Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Historically, the colistin has been thought to kill bacteria through membrane lysis. Here, we present an alternative mechanism that colistin induces rapid Paenibacillus polymyxa death through reactive oxygen species production. This significantly augments our understanding of the mechanism of colistin action, which is critical knowledge toward the yield development of colistin in the future.