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BioMed Research International
Volume 2017, Article ID 5470406, 9 pages
https://doi.org/10.1155/2017/5470406
Research Article

Corpuls CPR Generates Higher Mean Arterial Pressure Than LUCAS II in a Pig Model of Cardiac Arrest

1Institute for Translational Cardiac Surgery (INSURE), Department of Cardiovascular Surgery, German Heart Center Munich, Technische Universität München, Munich, Germany
2Fakultät für Informatik, Robotics and Embedded Systems, Technische Universität München, Munich, Germany
3GS Elektromedizinische Geräte GmbH, Kaufering, Germany
4Gene Center, LMU Munich, Munich, Germany
5German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany

Correspondence should be addressed to S. Eichhorn; moc.liamg@tsnrohhcie

Received 15 September 2017; Revised 25 October 2017; Accepted 23 November 2017; Published 17 December 2017

Academic Editor: Hideo Inaba

Copyright © 2017 S. Eichhorn et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

According to the European Resuscitation Council guidelines, the use of mechanical chest compression devices is a reasonable alternative in situations where manual chest compression is impractical or compromises provider safety. The aim of this study is to compare the performance of a recently developed chest compression device (Corpuls CPR) with an established system (LUCAS II) in a pig model. Methods. Pigs ( = 5/group) in provoked ventricular fibrillation were left untreated for 5 minutes, after which 15 min of cardiopulmonary resuscitation was performed with chest compressions. After 15 min, defibrillation was performed every 2 min if necessary, and up to 3 doses of adrenaline were given. If there was no return of spontaneous circulation after 25 min, the experiment was terminated. Coronary perfusion pressure, carotid blood flow, end-expiratory CO2, regional oxygen saturation by near infrared spectroscopy, blood gas, and local organ perfusion with fluorescent labelled microspheres were measured at baseline and during resuscitation. Results. Animals treated with Corpuls CPR had significantly higher mean arterial pressures during resuscitation, along with a detectable trend of greater carotid blood flow and organ perfusion. Conclusion. Chest compressions with the Corpuls CPR device generated significantly higher mean arterial pressures than compressions performed with the LUCAS II device.