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BioMed Research International
Volume 2017, Article ID 5489057, 6 pages
Research Article

The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke

1General Hospital, Unit of Neurology, Svetog Save Street No. 33, Berane, Montenegro
2Faculty of Medicine, University of Belgrade, Neurology Clinic, Clinical Center of Serbia, Dr. Subotica Street No. 6, 11 000 Belgrade, Serbia
3Faculty for Special Education and Rehabilitation, University of Belgrade, Visokog Stevana Street No. 2, 11 000 Belgrade, Serbia

Correspondence should be addressed to Dragan M. Pavlović; moc.liamtoh@35civolvapd

Received 11 January 2017; Revised 4 March 2017; Accepted 9 March 2017; Published 23 March 2017

Academic Editor: Vida Demarin

Copyright © 2017 Merdin Markišić et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We explored the relationship between acute ischaemic stroke (IS) early functional outcome and serum levels of homocysteine, vitamin B12, and D in a noninterventional prospective clinical study. We enrolled 50 patients with first-ever IS and performed laboratory tests and functional assessment at three time points: on admission and three and six months after stroke. Modified Rankin Scale (mRS), NIHSS scale, and Barthel index (BI) scores were assessed in all participants by trained examiner blinded to laboratory data. Patients did not receive treatment that might alter laboratory data. Admission NIHSS correlated with homocysteine levels (, ), B12 level (, ), and vitamin D levels (, ). Functional outcome measures (BI and mRS) did not significantly correlate with homocysteine and vitamin D3 levels at 3 and 6 months. However, a positive correlation with vitamin B12 levels was detected for BI both at 3 and 6 months and mRS at 6 months. Higher serum vitamin B12 levels were associated with better functional outcome at follow-up.