Research Article

Identification of Candidate Genes Related to Inflammatory Bowel Disease Using Minimum Redundancy Maximum Relevance, Incremental Feature Selection, and the Shortest-Path Approach

Table 1

Twenty-one important genes for IBD obtained using the mRMR and IFS methods.

GO term/KEGG pathway IDDescriptionRankGene symbolDescription

hsa04660T cell receptor signaling pathway3CD247CD247 molecule
19CD4CD4 molecule

GO: 0001775Cell activation5PF4Platelet factor 4

GO: 0045449 Regulation of transcription1ZNF207Zinc finger protein 207
8EGR3Early growth response 3
4SLTMSAFB-like, transcription modulator
14CNOT8CCR4-NOT transcription complex, subunit 8
13TH1L (NELFCD)Negative elongation factor complex member C/D
9HMGB1High mobility group box 1
12UBE2IUbiquitin-conjugating enzyme E2I

GO: 0007243Protein kinase cascade2MARK2MAP/microtubule affinity-regulating kinase 2

GO: 0031226Intrinsic to plasma membrane6FOLR1Folate receptor 1 (adult)
18SLC22A4Solute carrier family 22 (organic cation/zwitterion transporter), member 4
10LEPROTLeptin receptor overlapping transcript
16CLEC1BC-type lectin domain family 1, member B

GO: 0006915 Apoptosis21RHOT2ras homolog family member T2
7BLCAPBladder cancer associated protein

Non-grouped genes20ANXA11Annexin A11
15OGTO-linked N-acetylglucosamine (GlcNAc) transferase
17USPL1Ubiquitin specific peptidase like 1
11HIST1H2ACHistone cluster 1, H2ac

: this column indicates the ranks of related features in the mRMR feature list.