Identification of Candidate Genes Related to Inflammatory Bowel Disease Using Minimum Redundancy Maximum Relevance, Incremental Feature Selection, and the Shortest-Path Approach
Table 1
Twenty-one important genes for IBD obtained using the mRMR and IFS methods.
GO term/KEGG pathway ID
Description
Rank
Gene symbol
Description
hsa04660
T cell receptor signaling pathway
3
CD247
CD247 molecule
19
CD4
CD4 molecule
GO: 0001775
Cell activation
5
PF4
Platelet factor 4
GO: 0045449
Regulation of transcription
1
ZNF207
Zinc finger protein 207
8
EGR3
Early growth response 3
4
SLTM
SAFB-like, transcription modulator
14
CNOT8
CCR4-NOT transcription complex, subunit 8
13
TH1L (NELFCD)
Negative elongation factor complex member C/D
9
HMGB1
High mobility group box 1
12
UBE2I
Ubiquitin-conjugating enzyme E2I
GO: 0007243
Protein kinase cascade
2
MARK2
MAP/microtubule affinity-regulating kinase 2
GO: 0031226
Intrinsic to plasma membrane
6
FOLR1
Folate receptor 1 (adult)
18
SLC22A4
Solute carrier family 22 (organic cation/zwitterion transporter), member 4
10
LEPROT
Leptin receptor overlapping transcript
16
CLEC1B
C-type lectin domain family 1, member B
GO: 0006915
Apoptosis
21
RHOT2
ras homolog family member T2
7
BLCAP
Bladder cancer associated protein
Non-grouped genes
20
ANXA11
Annexin A11
15
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase
17
USPL1
Ubiquitin specific peptidase like 1
11
HIST1H2AC
Histone cluster 1, H2ac
: this column indicates the ranks of related features in the mRMR feature list.