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BioMed Research International
Volume 2017 (2017), Article ID 5813793, 15 pages
https://doi.org/10.1155/2017/5813793
Review Article

Therapeutic Potential of Epigallocatechin Gallate Nanodelivery Systems

UCIBIO, REQUIMTE, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal

Correspondence should be addressed to Marina Pinheiro

Received 31 March 2017; Revised 30 May 2017; Accepted 8 June 2017; Published 16 July 2017

Academic Editor: Sanyog Jain

Copyright © 2017 Andreia Granja et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nowadays, the society is facing a large health problem with the rising of new diseases, including cancer, heart diseases, diabetes, neurodegenerative diseases, and obesity. Thus, it is important to invest in substances that enhance the health of the population. In this context, epigallocatechin gallate (EGCG) is a flavonoid found in many plants, especially in tea. Several studies support the notion that EGCG has several benefits in fighting cancer, heart diseases, diabetes, and obesity, among others. Nevertheless, the poor intestinal absorbance and instability of EGCG constitute the main drawback to use this molecule in prevention and therapy. The encapsulation of EGCG in nanocarriers leads to its enhanced stability and higher therapeutic effects. A comprehensive review of studies currently available on the encapsulation of EGCG by means of nanocarriers will be addressed.