Review Article

Therapeutic Potential of Epigallocatechin Gallate Nanodelivery Systems

Table 5

Other EGCG nanocarriers. Note. N/A denotes “not available” data.

ParticleLoading capacity (%)Loading efficiency (%)Size (nm)Administration routeIn vitro/in vivo resultsRef.

SeleniumN/AN/A29N/AEnhanced capacity to inhibit Aβ fibrillation and promote fibril disaggregation. Protection of PC-12 against Aβ-mediated toxicity.[54]

TransfersomesN/A76.5101.2TopicalIncreased ability to suppress lipid peroxidation, ROS generation, and MMPs expression.
Enhanced ex vivo skin permeation and deposition of EGCG across rat skin.
[55]

Peptide dendrimers (glycine, proline, lysine, and arginine)N/AN/AN/ATopicalEnhanced ex vivo skin permeation and deposition of EGCG across rat skin.[56]

GelatinN/A97.13168.87OcularInhibition of HUVECs proliferation and migration.
Inhibition of vessel formation in a corneal neovascularization mouse model.
[57]

β-Lactoglobulin-chlorogenic acid~7.3~73~110N/AEnhanced EGCG stability in physiological environments. Controlled release in simulated gastric and intestinal environments.[58]