Research Article
Effects of Fungicides on Rat’s Neurosteroid Synthetic Enzymes
Figure 3
The kinetics of AKR1C14 and the inhibition of fungicides. Panel (a): kinetics of AKR1C14 with dihydrotestosterone (DHT) as the substrate. Panel (b): % inhibition by tebuconazole (TEB), triadimefon (TRI), and vinclozolin (VCZ) at 100 µM. Panel (c): IC50 value of TRI. Panel (d): the mode of inhibition of TRI versus DHT. Mean ± SEM; indicates a significant difference compared to the control (CON) at .
(a) 3α-HSD |
(b) 3α-HSD |
(c) 3α-HSD:TRI |
(d) TRI versus DHT |