Effects of Fungicides on Rat’s Neurosteroid Synthetic Enzymes

Scheme 2

The biosynthesis and metabolism of neurosteroids, allopregnanolone and androstanediol, by three distinct enzymes: NADPH-dependent 5α-reductase 1 (SRD5A1), NADPH-dependent cytosolic 3α-hydroxysteroid dehydrogenase (AKR1C14), and NAD⁺- dependent microsomal retinol dehydrogenase 2 (RDH2).