Renoprotective Effects of Aldose Reductase Inhibitor Epalrestat against High Glucose-Induced Cellular Injury

<div>Activation of ERK signaling pathway assessed after exposing NRK-52E cells to high glucose medium for 10 minutes, 30 minutes, 1 hour, 2 hours, and 4 hours. (a) Representative western blots of p-ERK1/2 and ERK1/2. (b) Densitometric analysis for p-ERK1 and (c) densitometric analysis for p-ERK2. Values were expressed as percentage Mean ± SEM <svg height="11.5564pt" id="M17" style="vertical-align:-2.26807pt" version="1.1" viewbox="-0.0498162 -9.28833 36.8666 11.5564" width="36.8666pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M300 -147C201 -63 143 98 143 270S200 602 300 686L282 710C136 610 70 450 70 271V270C70 89 136 -72 282 -170L300 -147Z" id="g113-41"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="346" vert-adv-y="346"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,4.498,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 381C387 381 393 374 378 305L329 95C309 17 320 -12 345 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BioMed Research International

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Figure 3

Figure 3: Renoprotective Effects of Aldose Reductase Inhibitor Epalrestat against High Glucose-Induced Cellular Injury 