Retrograde Activation of the Extrinsic Apoptotic Pathway in Spinal-Projecting Neurons after a Complete Spinal Cord Injury in Lampreys

<div>Photomicrographs of dorsal views of whole-mounted brains of larval sea lampreys showing FAM-LETD-FMK labeling in axotomized descending neurons 4 weeks after SCI ((a) and (b)). Rostral is to the top and the ventricle is to left in all figures. I1: Müller cell of the isthmic region; M1–M3: Müller cells 1 to 4. Scale bars: 50 <i>μ</i>m in (a) and 20 <i>μ</i>m in (b).</div>

BioMed Research International

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Figure 2

Figure 2: Retrograde Activation of the Extrinsic Apoptotic Pathway in Spinal-Projecting Neurons after a Complete Spinal Cord Injury in Lampreys 