Retrograde Activation of the Extrinsic Apoptotic Pathway in Spinal-Projecting Neurons after a Complete Spinal Cord Injury in Lampreys

Figure 3

Photomicrographs of dorsal views of the whole-mounted brain of larval sea lampreys showing the presence of intense FAM-DEVD-FMK labeling in “poor survivor” spinal-projecting neurons 10 weeks after a complete spinal cord transection ((b)–(d)) as compared to controls without injury (a). Note the absence of labeling in an I5 cell in (c). Rostral is to the top and the ventricle to the left in all figures. B1, B3, and B4: Müller cells of the bulbar region; I1 and I5: Müller cells of the isthmic region; M3: Müller cell 3; Mth: Mauthner cell. Scale bars: 50 μm in (a)–(c) and 15 μm in (d).

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