Retrograde Activation of the Extrinsic Apoptotic Pathway in Spinal-Projecting Neurons after a Complete Spinal Cord Injury in Lampreys

<div>Photomicrographs of dorsal views of whole-mounted brains of larval sea lampreys showing Fluoro-Jade C staining in swollen reticulospinal neurons 4 months after a complete SC transection (a). Note the absence of labeling in control animals without SC transection (b). The star indicates the location of the ventricle. Rostral is to the top in the figures. B1, B3, and B4: Müller cells of the bulbar region; Mth: Mauthner cell. Scale bars: 12.5 <i>μ</i>m.</div>

BioMed Research International

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Figure 4

Figure 4: Retrograde Activation of the Extrinsic Apoptotic Pathway in Spinal-Projecting Neurons after a Complete Spinal Cord Injury in Lampreys 