Review Article
Multiple Targets for Novel Therapy of FSGS Associated with Circulating Permeability Factor
Figure 1
(a) (i) Video micrograph of a glomerulus isolated from a normal rat. (ii) Cartoon of planar area traced from micrograph in medium containing 5% BSA. Diameters used to calculate glomerular volume are indicated as d1, d2, d3, and d4. (iii) Area after exposure to medium with 1% albumin concentration. (iv) Difference between images in 5% and 1% BSA. Increase in glomerular size is consequent to distension of glomerular capillaries. Calculations used to determine are detailed in the text |
(b) An example of the increase in glomerular volume in an untreated control glomerulus (solid line) and in a glomerulus after treatment with an injurious agent such as protamine (dotted line) as described previously [7, 8]. Here of the injured glomerulus is about 0.8. The figure has been redrawn from prior published figures |