Review Article

Multiple Targets for Novel Therapy of FSGS Associated with Circulating Permeability Factor

Figure 1

(a) (i) Video micrograph of a glomerulus isolated from a normal rat. (ii) Cartoon of planar area traced from micrograph in medium containing 5% BSA. Diameters used to calculate glomerular volume are indicated as d1, d2, d3, and d4. (iii) Area after exposure to medium with 1% albumin concentration. (iv) Difference between images in 5% and 1% BSA. Increase in glomerular size is consequent to distension of glomerular capillaries. Calculations used to determine are detailed in the text
(b) An example of the increase in glomerular volume in an untreated control glomerulus (solid line) and in a glomerulus after treatment with an injurious agent such as protamine (dotted line) as described previously [7, 8]. Here of the injured glomerulus is about 0.8. The figure has been redrawn from prior published figures