Review Article

Bioinformatics Genes and Pathway Analysis for Chronic Neuropathic Pain after Spinal Cord Injury

Table 1

Top 10 significantly enriched up- and downregulated DEGs. The values associated with each term are calculated by the Fisher Exact Test which represents the “degree of enrichment.” -value is the correction for multiple comparison by Benjamini and Hochberg [33]. The rank was according to the difference determined by d Score, fold change, and value. The top ten largest differences in DEGs were screen with fold change > 2 and , and the maximum change of gene expression profile was upregulation of Ccl3.

DEGsAccession numberSignal of controlSignal of experimentald ScoreFold change value-valueExpression change Rank

Ccl3NM_0113375.37 8.81 10.04 10.91 2.20E − 050Up1
Atf3NM_0074986.129.1810.108.370Up2
PlekNM_0195496.679.208.105.770Up3
Ctla2bNM_0011458015.457.908.085.450Up4
Bcl2a1aNM_0075347.239.598.375.140Up5
Ch25hNM_0098906.829.138.274.950Up6
PlekNM_0195495.878.127.584.760Up7
Tnfaip3NM_0011664025.757.458.123.240Up8
Tgif1NM_0011640746.057.598.522.910Up9
Gpr84NM_0307206.317.837.922.860Up10