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BioMed Research International
Volume 2017 (2017), Article ID 6560234, 12 pages
https://doi.org/10.1155/2017/6560234
Clinical Study

Lateral Ramus Cortical Bone Plate in Alveolar Cleft Osteoplasty with Concomitant Use of Buccal Fat Pad Derived Cells and Autogenous Bone: Phase I Clinical Trial

1Department of Oral and Maxillofacial Surgery, Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2University of Antwerp (UA), Antwerp, Belgium
3School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4Department of Orthodontics, Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6OMFS at the University of Antwerp, Antwerp, Belgium
7The Team for Cleft & Craniofacial Anomalies, Antwerp, Belgium
8Department of Hematology, Tarbiat Modares University, Tehran, Iran

Correspondence should be addressed to Arash Khojasteh; moc.oohay@hetsajohkhsara and Masoud Soleimani; ri.ca.seradom@m_mielos

Received 21 April 2017; Accepted 12 July 2017; Published 12 December 2017

Academic Editor: Joshua R. Mauney

Copyright © 2017 Arash Khojasteh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tissue regeneration has become a promising treatment for craniomaxillofacial bone defects such as alveolar clefts. This study sought to assess the efficacy of lateral ramus cortical plate with buccal fat pad derived mesenchymal stem cells (BFSCs) in treatment of human alveolar cleft defects. Ten patients with unilateral anterior maxillary cleft met the inclusion criteria and were assigned to three treatment groups. First group was treated with anterior iliac crest (AIC) bone and a collagen membrane (AIC group), the second group was treated with lateral ramus cortical bone plate (LRCP) with BFSCs mounted on a natural bovine bone mineral (LRCP+BFSC), and the third group was treated with AIC bone, BFSCs cultured on natural bovine bone mineral, and a collagen membrane (AIC+BFSC). The amount of regenerated bone was measured using cone beam computed tomography 6 months postoperatively. AIC group showed the least amount of new bone formation (%). LRCP+BFSC group demonstrated defect closure and higher amounts of new bone formation (%) but less than AIC+BFSC (%), suggesting that use of BFSCs within LRCP cage and AIC may enhance bone regeneration in alveolar cleft bone defects; however, the differences were not statistically significant. This clinical trial was registered at clinicaltrial.gov with NCT02859025 identifier.