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BioMed Research International
Volume 2017, Article ID 6594271, 10 pages
https://doi.org/10.1155/2017/6594271
Research Article

Genetic Variant of Kalirin Gene Is Associated with Ischemic Stroke in a Chinese Han Population

1Department of Cardiology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, China
2Department of Cardiology, The First Hospital of China Medical University, 155 North Nanjing Street, Shenyang 110001, China
3Department of Clinical Epidemiology, Library, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, China
4Epidemiology Department of China Medical University, No. 77 Puhe Road, Shenyang 110000, China

Correspondence should be addressed to Yingxian Sun; nc.ude.umc@nusxy

Received 11 February 2017; Revised 10 April 2017; Accepted 18 May 2017; Published 19 June 2017

Academic Editor: Maria Barbolina

Copyright © 2017 Hong Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Ischemic stroke is a complex disorder resulting from the interplay of genetic and environmental factors. Previous studies showed that kalirin gene variations were associated with cardiovascular disease. However, the association between this gene and ischemic stroke was unknown. We performed this study to confirm if kalirin gene variation was associated with ischemic stroke. Methods. We enrolled 385 ischemic stroke patients and 362 controls from China. Three SNPs of kalirin gene were genotyped by means of ligase detection reaction-PCR method. Data was processed with SPSS and SHEsis platform. Results. SNP rs7620580 (dominant model: OR = 1.590, p = 0.002 and adjusted OR = 1.662, p = 0.014; additive model: OR = 1.490, p = 0.002 and adjusted OR = 1.636, p = 0.005; recessive model: OR = 2.686, p = 0.039) and SNP rs1708303 (dominant model: OR = 1.523, p = 0.007 and adjusted OR = 1.604, p = 0.028; additive model: OR = 1.438, p = 0.01 and adjusted OR = 1.476, p = 0.039) were associated with ischemic stroke. The GG genotype and G allele of SNP rs7620580 were associated with a risk for ischemic stroke with an adjusted OR of 3.195 and an OR of 1.446, respectively. Haplotype analysis revealed that A–T–G,G-T-A, and A-T-A haplotypes were associated with ischemic stroke. Conclusions. Our results provide evidence that kalirin gene variations were associated with ischemic stroke in the Chinese Han population.