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BioMed Research International
Volume 2017, Article ID 6742183, 7 pages
Clinical Study

The Effect of Oral Dexmedetomidine Premedication on Preoperative Cooperation and Emergence Delirium in Children Undergoing Dental Procedures

1Department of Pediatric Dentistry, Faculty of Dentistry, Adnan Menderes University, Aydın, Turkey
2Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Adnan Menderes University, Aydın, Turkey

Correspondence should be addressed to Sultan Keles; moc.liamg@knatlustd

Received 10 June 2017; Revised 4 July 2017; Accepted 19 July 2017; Published 20 August 2017

Academic Editor: Christof Kolb

Copyright © 2017 Sultan Keles and Ozlem Kocaturk. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. The aim of this study was to detect the effect of 1 μg/kg of oral dexmedetomidine (DEX) as premedication among children undergoing dental procedures. Materials and Methods. The study involved 100 children between 2 and 6 years of age, ASA I, who underwent full-mouth dental rehabilitation. The DEX group () received 1 μg/kg DEX in apple juice, and the control group () received only apple juice. The patients’ scores on the Ramsay Sedation Scale (RSS), parental separation anxiety scale, mask acceptance scale, and pediatric anesthesia emergence delirium scale (PAEDS) and hemodynamic parameters were recorded. The data were analyzed using chi-square test, Fisher’s exact test, Student’s -test, and analysis of variance in SPSS. Results. RSS scores were significantly higher in the DEX group than group C at 15, 30, and 45 min (). More children (68% easy separation, 74% satisfactory mask acceptance) in the DEX group showed satisfactory ease of parental separation and mask acceptance behavior (). There was no significant difference in the PAEDS scores and mean hemodynamic parameters of both groups. Conclusions. Oral DEX administered at 1 μg/kg provided satisfactory sedation levels, ease of parental separation, and mask acceptance in children but was not effective in preventing emergence delirium. The trial was registered (Protocol Registration Receipt NCT03174678) at