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BioMed Research International
Volume 2017, Article ID 6840592, 9 pages
Research Article

Labor Induction with Orally Administrated Misoprostol: A Retrospective Cohort Study

1Department of Clinical Science and Education, Karolinska Institutet, Women’s Clinic, Sodersjukhuset, Sweden
2Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
3Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway
4Department of Women’s and Children’s Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

Correspondence should be addressed to Eva Wiberg-Itzel; moc.ailet@lezti.ave

Received 16 May 2017; Revised 11 July 2017; Accepted 25 July 2017; Published 18 September 2017

Academic Editor: Andrea Tinelli

Copyright © 2017 Tove Wallstrom et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. One great challenge in obstetric care is labor inductions. Misoprostol has advantages in being cheap and stable at room temperature and available in resource-poor settings. Material and Methods. Retrospective cohort study of 4002 singleton pregnancies with a gestational age ≥34 w at Sodersjukhuset, Stockholm, during 2009-2010 and 2012-2013. Previously used methods of labor induction were compared with misoprostol given as a solution to drink, every second hour. Main outcome is as follows: Cesarean Section (CS) rate, acid-base status in cord blood, Apgar score < 7,5′, active time of labor, and blood loss > 1500 ml (PPH). Results. The proportion of CS decreased from 26% to 17% when orally given solution of misoprostol was introduced at the clinic (). No significant difference in the frequency of low Apgar score (), low aPh in cord blood (), or PPH () between the different methods of induction was studied. After adjustment for different risk factor for CS the only method of induction which was associated with CS was (Propess®) (aor = 2.9 (1.6–5.2)). Conclusion. Induction of labor with misoprostol, given as an oral solution to drink every second hour, gives a low rate of CS, without affecting maternal or fetal outcome.