Investigation into Hypoglycemic, Antihyperlipidemic, and Renoprotective Potentials of Dennettia tripetala (Pepper Fruit) Seed in a Rat Model of Diabetes
Table 2
Subacute effect of crude methanol seed extract and fraction (CMEDT and MFDT) on plasma glucose level and body weight in streptozotocin-induced diabetic rats.
Group treatment (twice daily)
Initial body weight (g) Day 0
Final body weight (g) Day 10
Plasma glucose concentration (mg/dl)
% reduction
Day 0
Day 5
Day 10
Body weight
Glucose level
A: CMEDT 50 mg/kg body weight
↑
↓
36.62
75.82
B: CMEDT 100 mg/kg body weight
↓
46.77
43.78
C: MFDT 50 mg/kg body weight
42.31
41.85
D: MFDT 100 mg/kg body weight
↑
↓
22.95
71.34
E: glibenclamide 10 mg/kg body weight (positive control)
↓
24.56
79.91
F: negative (untreated) control
↓
↑
26.67
−21.11
G: normal control
1.61
13.65
-ratio
9.107
19.484
27.475
13.625
44.391
value
0.000
0.000
0.000
0.000
0.000
Values are mean ± SEM; = 5; < 0.05 when compared with normal control; < 0.05 when compared with negative (untreated) control; % reduction in plasma glucose level as compared to day 0. ↓ and ↑: decrease and increase.
