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BioMed Research International
Volume 2017, Article ID 6987240, 8 pages
https://doi.org/10.1155/2017/6987240
Research Article

Posttransplant Anemia as a Prognostic Factor of Mortality in Kidney-Transplant Recipients

1Fresenius Medical Care-Dialysis Services Slovakia, Kosice, Slovakia
2Graduate School Kosice Institute for Society and Health, Faculty of Medicine, Safarik University, Kosice, Slovakia
3Department of Health Psychology, Faculty of Medicine, Safarik University, Kosice, Slovakia
4Transplantation Department, Faculty of Medicine and University Hospital, Safarik University, Kosice, Slovakia
5St. Lukas Geriatric Centre, Kosice, Slovakia
6Department of Community & Occupational Health, University Medical Centre Groningen, University of Groningen, Groningen, Netherlands

Correspondence should be addressed to Maria Majernikova; moc.liamg@nrejamam

Received 19 May 2016; Revised 29 August 2016; Accepted 26 February 2017; Published 19 March 2017

Academic Editor: Houry Puzantian

Copyright © 2017 Maria Majernikova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Findings on the association between posttransplant anemia (PTA) and mortality in posttransplant patients are scarce. This study explored whether PTA shortly after kidney transplantation (KT) predicts mortality at up to 10 years’ follow-up, stratified for chronic kidney disease (CKD) stages. Methods. PTA was divided into 3 categories according to the hemoglobin (Hb) value: severe (Hb < 10 g/dl), mild (10.0 g/dl ≤ Hb < 11.9 g/dl), or no PTA (Hb ≥ 12 g/dl). CKD stages were estimated using the CKD-EPI formula and divided into 2 groups: CKD1-2 and CKD3–5. Cox regression, stratified according to CKD, was performed to identify whether different categories of PTA predicted mortality in KT recipients. Results. Age, being female, and both mild and severe PTA contributed significantly to the Cox regression model on mortality in CKD1-2. In the Cox regression model for mortality in CKD3–5, age and severe PTA contributed significantly to this model. Conclusion. PTA shortly after KT increased the risk of mortality at up to 10 years’ follow-up. Even mild PTA is associated with a 6-fold higher risk of mortality and severe PTA with a 10-fold higher risk of mortality in CKD1-2. Clinical evaluation and treatment of anemia might reduce the higher risk of mortality in patients with PTA in early stages of CKD after KT.