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BioMed Research International
Volume 2017, Article ID 7124817, 9 pages
https://doi.org/10.1155/2017/7124817
Research Article

Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications

1Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, 1, Sec. 3, Zhongxiao E. Rd., Taipei 10608, Taiwan
2Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County 35053, Taiwan

Correspondence should be addressed to Hsu-Wei Fang; wt.ude.tutn@gnafwh

Received 13 July 2017; Revised 20 September 2017; Accepted 27 September 2017; Published 13 November 2017

Academic Editor: Liping Wang

Copyright © 2017 Chen-Ying Su et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Many external stimulations have been shown to promote bone regeneration. The effects of an alternating current (AC) electrostatic field, one of external stimulations, generated from a device with high voltage and low current output on human osteoblastic cell line have been investigated in this study. We investigated how human osteoblasts responded to an AC electrostatic field, and the output parameters were set as 1 kV and 160 μA. Our results showed that, under such condition, the AC electrostatic field had a downregulation effect on the production ability of alkaline phosphatase and type 1 collagen expression. However, the expression of osteocalcin gene was elevated on the end of EFID treatment suggesting that AC electrostatic field might be a potential stimulation for accelerating the differentiation of osteoblastic cells.