Comparison of the Protective Effects of Individual Components of Particulated trans-Sialidase (PTCTS), PTC and TS, against High Cholesterol Diet-Induced Atherosclerosis in Rabbits

Table 1

Circulating levels of total cholesterol, HDL cholesterol, non-HDL (n-HDL) cholesterol, and triglycerides in serum from control and treated groups at basal, pretreatment, and posttreatment phases. The difference between pretreatment and posttreatment stages () is represented. Data are expressed as mean ± SD. Comparison between groups was performed using a paired t-test.

	Basal	Pretreatment	Posttreatment		Basal × pre	Pre × post
						Total cholesterol (mg/dL)
CNeg	100 ± 85	88 ± 43	84 ± 55	−4 ± 17	0.32	0.58
CPos	65 ± 39	979 ± 274	1418 ± 383	439 ± 345	<0.001	0.03
PTC	74 ± 51	1183 ± 318	1534 ± 426	352 ± 586	<0.001	0.2
TS	74 ± 36	971 ± 145	960 ± 376	−9 ± 336	<0.001	0.95
PTCTS	89 ± 56	968 ± 293	1137 ± 273	169 ± 120	<0.001	0.02
	HDL (mg/dL)
CNeg	37 ± 19	42 ± 17	32 ± 20	−10 ± 18	0.17	0.22
CPos	32 ± 17	506 ± 279	445 ± 131	−61 ± 193	0.004	0.47
PTC	32 ± 18	531 ± 91	487 ± 125	−44 ± 123	<0.001	0.42
TS	42 ± 14	615 ± 189	344 ± 137	−225 ± 205	0.001	0.03
PTCTS	39 ± 20	573 ± 158	442 ± 98	−131 ± 140	<0.001	0.07
	n-HDL (mg/dL)
CNeg	63 ± 75	46 ± 31	52 ± 37	6 ± 14	0.26	0.33
CPos	33 ± 25	473 ± 193	973 ± 385	500 ± 256	0.002	0.005
PTC	42 ± 34	652 ± 292	1047 ± 375	395 ± 502	0.002	0.11
TS	32 ± 24	357 ± 206	616 ± 333	216 ± 246	0.01	0.08
PTCTS	50 ± 37	395 ± 395	696 ± 197	300 ± 229	0.01	0.02
	Triglycerides (mg/dL)
CNeg	83 ± 27	56 ± 26	203 ± 335	147 ± 349	0.1	0.44
CPos	83 ± 59	134 ± 50	377 ± 201	244 ± 210	0.1	0.04
PTC	77 ± 27	205 ± 115	600 ± 556	396 ± 562	0.02	0.14
TS	51 ± 18	94 ± 44	344 ± 322	208 ± 277	0.02	0.12
PTCTS	69 ± 27	119 ± 91	386 ± 225	267 ± 139	0.35	0.005