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BioMed Research International
Volume 2017, Article ID 7275109, 10 pages
https://doi.org/10.1155/2017/7275109
Research Article

Ameliorating Effect of Gemigliptin on Renal Injury in Murine Adriamycin-Induced Nephropathy

1Department of Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea
2Division of Nephrology, Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Republic of Korea
3Department of Nephrology, Kyung Hee University School of Medicine, Seoul, Republic of Korea
4Division of Nephrology, Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea

Correspondence should be addressed to Kyung Hwan Jeong; moc.revan@nawhlirpa

Received 4 December 2016; Accepted 30 January 2017; Published 23 February 2017

Academic Editor: Beatrice Charreau

Copyright © 2017 Da Rae Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Boonacker and C. J. F. Van Noorden, “The multifunctional or moonlighting protein CD26/DPPIV,” European Journal of Cell Biology, vol. 82, no. 2, pp. 53–73, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. N. Wronkowitz, S. W. Görgens, T. Romacho et al., “Soluble DPP4 induces inflammation and proliferation of human smooth muscle cells via protease-activated receptor 2,” Biochimica et Biophysica Acta—Molecular Basis of Disease, vol. 1842, no. 9, pp. 1613–1621, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. H. S. Min, J. E. Kim, M. H. Lee et al., “Dipeptidyl peptidase IV inhibitor protects against renal interstitial fibrosis in a mouse model of ureteral obstruction,” Laboratory Investigation, vol. 94, no. 6, pp. 598–607, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. E. Jung, J. Kim, S. Ho Kim, S. Kim, and M.-H. Cho, “Gemigliptin improves renal function and attenuates podocyte injury in mice with diabetic nephropathy,” European Journal of Pharmacology, vol. 761, pp. 116–124, 2015. View at Publisher · View at Google Scholar · View at Scopus
  5. C. Tiruppathi, Y. Miyamoto, V. Ganapathy, R. A. Roesel, G. M. Whitford, and F. H. Leibach, “Hydrolysis and transport of proline-containing peptides in renal brush-border membrane vesicles from dipeptidyl peptidase IV-positive and dipeptidyl peptidase IV-negative rat strains,” Journal of Biological Chemistry, vol. 265, no. 3, pp. 1476–1483, 1990. View at Google Scholar · View at Scopus
  6. C. Maric, K. Sandberg, and C. Hinojosa-Laborde, “Glomerulosclerosis and tubulointerstitial fibrosis are attenuated with 17β-estradiol in the aging Dahl salt sensitive rat,” Journal of the American Society of Nephrology, vol. 15, no. 6, pp. 1546–1556, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Mera, S. Uchida, and M. Nagase, “Clinicopathologic study on prognostic markers in IgA nephropathy,” Nephron, vol. 84, no. 2, pp. 148–157, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Fukuda, L. T. Wickman, M. P. Venkatareddy et al., “Angiotensin II-dependent persistent podocyte loss from destabilized glomeruli causes progression of end stage kidney disease,” Kidney International, vol. 81, no. 1, pp. 40–55, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Lydia, K. Asanuma, K. Nonaka et al., “Effects of 22-oxa-calcitriol on podocyte injury in adriamycin-induced nephrosis,” American Journal of Nephrology, vol. 35, no. 1, pp. 58–68, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Makdissi, H. Ghanim, M. Vora et al., “Sitagliptin exerts an antinflammatory action,” Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 9, pp. 3333–3341, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. F. Reis, L. Ferreira, E. Teixeira-De-Lemos et al., “Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes (ZDF rat),” Mediators of Inflammation, vol. 2010, Article ID 592760, 11 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Shinjo, Y. Nakatsu, M. Iwashita et al., “DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation,” American Journal of Physiology—Endocrinology and Metabolism, vol. 309, no. 3, pp. E214–E223, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. A. H. Sprague and R. A. Khalil, “Inflammatory cytokines in vascular dysfunction and vascular disease,” Biochemical Pharmacology, vol. 78, no. 6, pp. 539–552, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Qian, H. You, Q. Zhu et al., “Nitrotyrosine level was associated with mortality in patients with acute kidney injury,” PLOS ONE, vol. 8, no. 11, Article ID e79962, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Babelova, D. Avaniadi, O. Jung et al., “Role of Nox4 in murine models of kidney disease,” Free Radical Biology and Medicine, vol. 53, no. 4, pp. 842–853, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. S. W. Lim, L. Jin, S. G. Piao, B. H. Chung, and C. W. Yang, “Inhibition of dipeptidyl peptidase IV protects tacrolimus-induced kidney injury,” Laboratory Investigation, vol. 95, no. 10, pp. 1174–1185, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Higashijima, T. Tanaka, J. Yamaguchi, S. Tanaka, and M. Nangaku, “Anti-inflammatory role of DPP-4 inhibitors in a nondiabetic model of glomerular injury,” American Journal of Physiology—Renal Physiology, vol. 308, no. 8, pp. F878–F887, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. G. Remuzzi and T. Bertani, “Pathophysiology of progressive nephropathies,” The New England Journal of Medicine, vol. 339, no. 20, pp. 1448–1456, 1998. View at Publisher · View at Google Scholar · View at Scopus
  19. S. J. Shankland, “The podocyte's response to injury: role in proteinuria and glomerulosclerosis,” Kidney International, vol. 69, no. 12, pp. 2131–2147, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Camici, “Urinary biomarkers of podocyte injury,” Biomarkers in Medicine, vol. 2, no. 6, pp. 613–616, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. H. Yuan, E. Takeuchi, and D. J. Salant, “Podocyte slit-diaphragm protein nephrin is linked to the actin cytoskeleton,” American Journal of Physiology—Renal Physiology, vol. 282, no. 4, pp. F585–F591, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Doublier, V. Ruotsalainen, G. Salvidio et al., “Nephrin redistribution on podocytes is a potential mechanism for proteinuria in patients with primary acquired nephrotic syndrome,” American Journal of Pathology, vol. 158, no. 5, pp. 1723–1731, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. P. N. Furness, L. L. Hall, J. A. Shaw, and J. H. Pringle, “Glomerular expression of nephrin is decreased in acquired human nephrotic syndrome,” Nephrology Dialysis Transplantation, vol. 14, no. 5, pp. 1234–1237, 1999. View at Publisher · View at Google Scholar · View at Scopus
  24. P. V. Hauser, F. Collino, B. Bussolati, and G. Camussi, “Nephrin and endothelial injury,” Current Opinion in Nephrology and Hypertension, vol. 18, no. 1, pp. 3–8, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. X. Li, P. Y. Chuang, V. D. D'Agati et al., “Nephrin preserves podocyte viability and glomerular structure and function in adult kidneys,” Journal of the American Society of Nephrology, vol. 26, no. 10, pp. 2361–2377, 2015. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. B. Y. Sun, X. Qu, X. Zhang, G. Caruana, J. F. Bertram, and J. Li, “Glomerular endothelial cell injury and damage precedes that of podocytes in adriamycin-induced nephropathy,” PLoS ONE, vol. 8, no. 1, Article ID e55027, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. V. W. Lee and D. C. Harris, “Adriamycin nephropathy: a model of focal segmental glomerulosclerosis,” Nephrology, vol. 16, no. 1, pp. 30–38, 2011. View at Publisher · View at Google Scholar · View at Scopus