The Interaction between GSTT1, GSTM1, and GSTP1 Ile105Val Gene Polymorphisms and Environmental Risk Factors in Premalignant Gastric Lesions Risk

Table 2

Effect of the studied gene polymorphisms on the outcome variable.

	Without endoscopic lesions versus mild or severe endoscopic lesions (169/101)		value	Adjusted [95% CI]	Without premalignant lesions versus with premalignant lesions (141/129)		value	Adjusted (95% CI)
GSTP1 Ile105Val
Ile/Ile	85	61			68	78
Ile/Val + Val/Val	84	40	0.116	0.67 [0.4, 1.11]	73	51	0.038	0.60 [0.37, 0.98]
GSTT1
T1	134	80			110	104
Null	35	21	0.844	0.94 [0.50, 1.74]	31	25	0.627	0.86 [0.47, 1.57]
GSTM1
M1	90	44			77	57
Null	79	57	0.106	1.51 [0.92, 2.52]	64	72	0.074	1.55 [0.96, 2.53]
GSTT1/M1
T1/M1	70	33			60	43
T1/null	64	47	0.115	1.58 [0.90, 2.79]	50	61	0.050	1.72 [1.00, 2.97]
Null/M1	20	11	0.873	1.07 [0.44, 2.49]	17	14	0.774	1.15 [0.50, 2.58]
Null/null	15	10	0.492	1.38 [0.54, 3.49]	14	11	0.757	1.15 [0.46, 2.84]

eference category; CI = confidence level: [lower limit; upper limit]; was adjusted by age and sex.