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BioMed Research International
Volume 2017, Article ID 7367831, 8 pages
Research Article

Vitamin B-6, Independent of Homocysteine, Is a Significant Factor in Relation to Inflammatory Responses for Chronic Kidney Disease and Hemodialysis Patients

1Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan
2Division of Basic Medical Sciences, Department of Medical Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan
3Department of Life Science, Tunghai University, Taichung 40705, Taiwan
4Graduate Program in Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan
5Division of Nephrology, Department of Internal Medicine, Chiayi Branch, Taichung Veterans General Hospital, Chiayi 60090, Taiwan
6Department of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan
7Department of Nutrition, Chung Shan Medical University Hospital, Taichung 40201, Taiwan

Correspondence should be addressed to Yi-Chia Huang; wt.ude.umsc@hcy

Received 6 June 2017; Revised 11 August 2017; Accepted 20 August 2017; Published 26 September 2017

Academic Editor: Charnita M. Zeigler-Johnson

Copyright © 2017 Cheng-Hsu Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The purpose of this study was to investigate whether plasma pyridoxal 5′-phosphate (PLP) and homocysteine were dependent on or independent of each other in order to be associated with inflammatory markers in patients with chronic kidney disease (CKD) or those receiving hemodialysis treatment. This was a cross-sectional study. Sixty-eight stage 2–5 CKD patients and 68 hemodialysis patients had one time fasting blood drawn for measurements of plasma PLP, pyridoxal (PL), homocysteine, and several inflammatory markers. Early CKD stage (stages 2-3) patients showed significantly lower plasma PLP levels and homocysteine concentrations than patients in an advanced CKD stage (stages 4-5) and those undergoing hemodialysis. Plasma PLP significantly correlated with CRP levels (partial = −0.21, ) and plasma PL significantly correlated with IL-10 levels (partial = −0.24, ), while plasma PLP plus PL significantly correlated with both CRP levels (partial = −0.20, ) and interleukin-1β (partial = 0.22, ) levels after adjusting for plasma homocysteine and other potential confounders. Plasma homocysteine displayed no significant correlations with any inflammatory markers. Vitamin B-6 status, rather than homocysteine, appeared to be a significant factor in relation to inflammatory responses for CKD and hemodialysis patients.