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BioMed Research International
Volume 2017 (2017), Article ID 7403747, 12 pages
https://doi.org/10.1155/2017/7403747
Review Article

Apoptotic Signaling Pathways in Glioblastoma and Therapeutic Implications

1Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
2Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
3Unidad Periférica de Investigación en Biomedicina Translacional, ISSSTE C.M.N. 20 de Noviembre, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico

Correspondence should be addressed to Marco A. Velasco-Velázquez; xm.manu@ocsalevocram and Aliesha González-Arenas; moc.liamg@zelaznogahseila

Received 28 July 2017; Revised 22 September 2017; Accepted 28 September 2017; Published 12 November 2017

Academic Editor: Francesco Pasqualetti

Copyright © 2017 Silvia Anahi Valdés-Rives et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Glioblastoma multiforme (GBM) is the most hostile type of brain cancer. Its aggressiveness is due to increased invasion, migration, proliferation, angiogenesis, and a decreased apoptosis. In this review, we discuss the role of key regulators of apoptosis in GBM and glioblastoma stem cells. Given their importance in the etiology and pathogenesis of GBM, these signaling molecules may represent potential therapeutic targets.