Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ_1–42-Induced Rat Model of Alzheimer’s Disease

Figure 4

Effect of ICA on the expression of BDNF and pCREB in immunoreactive cells in the hippocampi of -infused rats. (a) Representative immunohistochemistry images of BDNF and pCREB expression in the sham, vehicle, ICA-L, ICA-M, and ICA-H groups (/group). The selected CA1 regions are shown in the first (BDNF) and third (pCREB) columns, and the selected CA2/3 regions are shown in the second (BDNF) and forth (pCREB) columns (amplification ×100). The arrows indicate immunopositive cells. (b) Representative immunohistochemistry images of BDNF (left) and pCREB (right) in the hippocampus (amplification ×40). (c) Statistical graph showing the OD of BDNF. (d) Statistical graph showing the OD of pCREB. The results are expressed as the percentage relative to the sham group. All data were analysed using one-way ANOVA and are presented as the mean ± SD. and versus the vehicle group. versus the ICA-H group.

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