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BioMed Research International
Volume 2017, Article ID 7868645, 9 pages
https://doi.org/10.1155/2017/7868645
Research Article

The PDZ-Binding Motif of HPV16-E6 Oncoprotein Modulates the Keratinization and Stemness Transcriptional Profile In Vivo

1Genetics and Cancer Research Unit, Hospital Juárez de México (HJM), 07760 Mexico City, Mexico
2Oncogenomic Department, Instituto Nacional de Medicina Genómica (INMEGEN), 14610 Mexico City, Mexico
3Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
4Department of Cellular Biology, Centro de Investigación y de Estudios Avanzados (Cinvestav), 07360 Mexico City, Mexico
5Department of Physiology, Biophysics, and Neurosciences, Centro de Investigación y de Estudios Avanzados (Cinvestav), 07360 Mexico City, Mexico
6Laboratory of Clinic Research, Unidad Académica de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero (UAGro), 39070 Chilpancingo de los Bravo, GRO, Mexico
7Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados (Cinvestav), 07360 Mexico City, Mexico

Correspondence should be addressed to Patricio Gariglio; xm.vatsevnic@ladiv and José Bonilla-Delgado; xm.vatsevnic@allinobj

Received 9 March 2017; Revised 24 July 2017; Accepted 24 August 2017; Published 10 October 2017

Academic Editor: Henry Wong

Copyright © 2017 Enoc Mariano Cortés-Malagón et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure 1 (Caption): A complete list of differentially expressed genes from K14E6 vs. K14E6d146-151 mice transcriptional profiles.

Supplementary Figure 1 (Figure text): The list shows differentially up- or down-regulated genes resulted from global transcriptional microarray experiments.

Supplementary Figure 2 (Caption): Histogram of wound closure of ears.

Supplementary Figure 2 (Figure text): The histogram shows the distribution frequencies of wound closure every 0.1 mm in the ears of each mice strain. NTG: 24 samples, K14E6: 28 samples, and K14E6d146-151: 12 samples.

  1. Supplementary Material