Efficacy of Platelet-Rich Plasma in Retarding Intervertebral Disc Degeneration: A Meta-Analysis of Animal Studies

Table 1

Characteristics of the included studies.

First author	Publication year	Country	Manuscript language	Animal species	Disc degeneration model	Study design	Observation time (weeks)	PRP description
Nagae et al. [36]	2007	Japan	English	Rabbit	Nucleus pulposus aspiration	N-RCT	8	Autologous
Sawamura et al. [26]	2009	Japan	English	Rabbit	Nucleus pulposus aspiration	N-RCT	8	Autologous
Chen et al. [29]	2009	China	English	Pig	Chymopapain induction	N-RCT	8	Allogenic
Gullung et al. [34]	2011	USA	English	Rat	Needle puncture	RCT	4	Not available
Hu et al. [40]	2012	China	Chinese	Rabbit	Needle puncture	RCT	2	Autologous
Obata et al. [37]	2012	Japan	English	Rabbit	Needle puncture	N-RCT	8	Autologous
Meng et al. [42]	2013	China	Chinese	Rabbit	Needle puncture	RCT	8	Allogenic
Gui et al. [41]	2015	China	Chinese	Rabbit	Needle puncture	RCT	2	Autologous
Gui et al. [33]	2015	China	English	Rabbit	Needle puncture	RCT	6	Autologous
Wang et al. [38]	2016	China	English	Rabbit	Needle puncture	RCT	8	Allogenic
Yang et al. [39]	2016	China	English	Rabbit	Needle puncture	RCT	12	Autologous

RCT: randomized controlled trial; N-RCT: nonrandomized controlled trial.